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TranscriptomicsPI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis
This SuperSeries is composed of the following subset Series: GSE25170: MYC drives resistance to PI3K/mTOR targeted inhibition (Sty SNP array) GSE25172: MYC drives resistance to PI3K/mTOR targeted inhibition (gene expression) Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-25173 | biostudies-arrayexpress
TranscriptomicsMYC drives resistance to PI3K/mTOR targeted inhibition (Sty SNP array)
Genomic copy-number changes were measured using 250K StyI SNP arrays after selection of cells to enrich for resistance to BEZ235. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted using Qiagen DNeasy from engineered human cell-lines. Resulting alteratio...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25170 | biostudies-arrayexpress
TranscriptomicsMYC drives resistance to PI3K/mTOR targeted inhibition (gene expression)
Gene expression signatures were measured after treatment of cells with 50nM BEZ235. Affymetrix HG-U133AV2 expression arrays were performed according to the manufacturer's directions using RNA extracted by Qiagen RNeasy from engineered human cell-lines grown for 72h in the presence of 50nM BEZ235 Res...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25172 | biostudies-arrayexpress
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