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TranscriptomicsDifferential gene expression after ingenol mebutate (IM) treatment
We treated primary keratinocytes and SCC cells with IM for 24h to identify differentially expressed genes after treatment compared to DMSO contorl 3x DMSO keratinocytes, 3x IM 100 nM IM keratinocytes, 3x 10 uM IM keratinocytes, 3x DMSO SCC cells, 3x 1 nM IM SCC cells, 3x 100 nM IM SCC cells, 3x 10 u...
ORGANISM(S): Homo sapiens 
2015-05-03 | E-GEOD-63308 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile Lactobacillus plantarum WCFS1 : p-coumaric acid (p-CA) treated cells
Whole genome transcriptional profiling was used to characterize the response of Lactobacillus plantarum WCFS1 human isolate during challenge with p-coumaric acid (p-CA). Twelve independent experiments were performed and mixed at random in groups of four for total of three RNA samples. The transcript...
ORGANISM(S): Lactobacillus plantarum 
2013-01-16 | E-GEOD-40126 | biostudies-arrayexpress
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
ProteomicsAP-MS analysis of human histone deacetylase interactions in CEM-T cells
Affinity purification-mass spectrometry (AP-MS) datasets of eleven human histone deacetylases (HDACs). Affinity-tagged (GFP) HDACs were expressed in a human CEM-T cell line. For label-free analysis, proteins were digested by trypsin in-solution and peptides separated across a linear 180 min gradient...
ORGANISM(S): Homo sapiens (Human) 
2013-06-14 | PXD000208 | Pride
Ap-ms Protein interactions Hdac Idirt 
TranscriptomicsLacerated muscle gene expression
We investigated the inflammatory gene profile of surgically-repaired lacerated muscles during the recovery phase and examined if it was influenced by the integrity/injury of the IM, intramuscular nerve using 3 lacerated rat muscle models: DN, where the IM-nerve was concomitantly cut; RN, where the I...
ORGANISM(S): Rattus Norvegicus 
2012-01-11 | E-MTAB-755 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq)
Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing techno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36242 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to benzo[a]pyrene treatment in HepG2 cells
This SuperSeries is composed of the following subset Series: GSE36242: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq) GSE36243: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36244 | biostudies-arrayexpress
UnknownDetection of AP-237 and synthetic cannabinoids on an infused letter sent to a German prisoner.
Not available
S-EPMC9804899 | biostudies-literature
TranscriptomicsTranscriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix)
Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing techno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36243 | biostudies-arrayexpress
TranscriptomicsComparison of the transcriptional response to ethanol in laboratory and wild yeast strains
An S288c-derived lab strain of Saccharomyces cerevisiae has lower ethanol resistance than either the vineyard strain M22 or the oak strain YPS163. We performed a 60 minute time-course experiment in the presence of 5% ethanol and compared the transcriptional response to ethanol between strains. We ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-17 | E-GEOD-22904 | biostudies-arrayexpress
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