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Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs). Its prevention is based on the detection and treatment of traditional cardiovascular risk factors1 but often fails to identify individuals at risk for early vascular disease2. Recent research has suggested new players in...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD063955 | Pride
RNAseq analysis of H69 cholangiocyte cell line stimulated with imidazole propionate
Imidazole propionate (ImP): effect on human aortic endothelial cells
The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the bile ducts associated with inflammatory bowel disease and an altered gut microbiota. Here we studied the transcriptomic impact of the gut microbial metabolite imidazole propionate and its precursor urocanate on a human cho...
ORGANISM(S): Homo sapiens 
2026-08-10 | GSE341409 | GEO
Imidazole propionate is a driver and therapeutic target in atherosclerosis [scRNA-seq]
The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...
ORGANISM(S): Danio rerio 
Imidazole propionate is an early biomarker and therapeutic target for atherosclerosis [bulk RNA-seq]
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