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UnknownMetabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.
Not available
S-EPMC6214769 | biostudies-literature
UnknownMechanisms of imipridones in targeting mitochondrial metabolism in cancer cells.
Not available
S-EPMC8041338 | biostudies-literature
ProteomicsImipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease
Ectopic activation of the conserved ClpP protease by chemical activators causes toxicity in bacteria and human cells due to unrestrained proteolysis. The imipridone ONC201 has been ascribed multiple mechanisms of action and is currently in cancer clinical trials. To systematically investigate the ge...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2020-03-26 | PXD016119 | Pride
Imipridones Clpp protease 
UnknownImipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.
Not available
S-EPMC11589887 | biostudies-literature
UnknownONC201 and imipridones: Anti-cancer compounds with clinical efficacy.
Not available
S-EPMC7588802 | biostudies-literature
UnknownImipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT.
Not available
S-EPMC11948724 | biostudies-literature
UnknownReduced EZH1/2 expression in imipridone-treated cells correlates with synergy following combinations with EZH1/2 or HDAC inhibitors in diffuse glioma and other tumors.
Not available
S-EPMC11982711 | biostudies-literature
UnknownMitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Not available
S-EPMC6620028 | biostudies-literature
UnknownPotent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Not available
S-EPMC8493379 | biostudies-literature
UnknownImipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
Not available
S-EPMC9435508 | biostudies-literature
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