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MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
MetabolomicsMetabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
MetabolomicsGut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights
MetabolomicsButyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.

2026-06-26 | MTBLS14301 | MetaboLights
MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
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