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MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
MetabolomicsACOD1 deficiency promotes dermal papilla cell senescence via mitochondrial dysfunction in androgenetic alopecia

Background Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by the dysfunction of dermal papilla cells (DPCs). Emerging evidence implicates DPC senescence in the pathogenesis of AGA; however, the underlying molecular mechanisms remain incompletely elucidated.

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2026-05-23 | MTBLS14024 | MetaboLights
TranscriptomicsPathway Profiling of Replicative and Induced Senescence
RNA-seq was performed on LFS MDAH041 cells that were young (PD10-12), aging (PD17-19) and replicatively senescent (PD28-30), as well as spontaneously immortal cells and cells that were induced into senescence or quiescence, in order to profile the pathways common in all 4 types of sensecence and th...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-60340 | biostudies-arrayexpress
TranscriptomicsCellular senescence reprograms human NK cells to promote vascular remodeling
Natural killer (NK) cells are lymphocytes that participate in immune responses through their cytotoxic activity and secretion of cytokines and chemokines. They can be activated by interaction with ligands on target cells or by soluble mediators such as cytokines. In addition, soluble HLA-G, a major ...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-35330 | biostudies-arrayexpress
TranscriptomicsHuman regulatory T cells induce lymphocyte senescence
Analysis of gene alternations during the process of senescence induced by human regulatory T cells at various time points. Total RNA obtained from isolated regulatory T (Treg) cell-treated responder CD8+ T cells compared to the untreated T cells
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-38765 | biostudies-arrayexpress
TranscriptomicsDepletion of HPV16 oncogenes induces autophagy and senescence in a cervical carcinogenesis model, irrespective of viral physical state
We utilised our in vitro model of cervical neoplastic progression, W12, to investigate the effect of HPV16 viral oncogene depletion on well-defined integrant- and episome- associated series. To target HPV16 viral oncogenes we used our previously published E7-targeting siRNA sequence that caused subs...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-MTAB-1331 | biostudies-arrayexpress
TranscriptomicsIdentity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow (II)
Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating diseases for which currently no therapeutic options exist. High quantities of MSCs are needed, requiring extensive cell expansion in long-term culture. However, the fundamental biological properties of MSCs can be altered ...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-68931 | biostudies-arrayexpress
MetabolomicsRectal microbiomes and serum metabolomics reveal changes in serum antioxidant status and immune responses of Dezhou donkeys in late gestation to parturition

Background: Parturition is a critical event in the reproductive cycle of dairy animals, accompanied by multiple physiological changes in sex hormones, metabolism, antioxidant capacity and immune function. However, the changes in the rectal microbiota and metabolic products of Jennies from late ge...

2025-08-27 | MTBLS12897 | MetaboLights
GenomicsCancer immune control needs senescence induction by Stat1 dependent cell cycle regulator pathways in tumours
Immune checkpoint bloackade (ICB)-based or natural cancer immune responses largely eliminate tumours. Yet, they require additional mechanisms to arrest those cancer cells that are not rejected. Cytokine-induced senescence (CIS) can stably arrest cancer cells, suggesting that interferon-dependent ind...
EGAS00001004151 | EGA
GenomicsNRF1-mediated Innate Immune Response Drives Cellular Senescence and Aging
NRF1-mediated Innate Immune Response Drives Cellular Senescence and Aging
PRJNA1250455 | ENA
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