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ProteomicsEnhanced Proteomic Coverage in Tissue Microenvironment by Immune Cell Subtype Library-assisted DIA-MS
The objective of the protject is to develop an immune cell-enrich library-assisted DIA method that enables the comprehensive identification and quantification of immunological proteins from micro-scale samples with high sensitivity. In the project, six immune cell subtype-specific libraries includin...
ORGANISM(S): Mus Musculus (mouse) 
2025-01-18 | PXD048670 | JPOST Repository
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
MetabolomicsTargeted metabolomics of pancancer brain metastasis

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we constructed a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes ...

2025-12-22 | MTBLS13554 | MetaboLights
GenomicsImmune subtype of ovarian clear cell carcinoma
Immune subtype of ovarian clear cell carcinoma
PRJNA529652 | ENA
GenomicsImmune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
PRJNA833469 | ENA
ProteomicsFaecal Proteases and Immune Signatures Drive Subtype-Specific Enteric Neuronal Activation in IBS
Background: Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknown. We investigated whether ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD071836 | Pride
Protease-activated receptors (pars) Irritable bowel syndrome Serine and cysteine protease activity Faecal supernatant proteomics Luminal–neuronal signalling axis 
GenomicsThe landscape of immune cells in the mouse HCC model with F1 and F3 subtype
The landscape of immune cells in the mouse HCC model with F1 and F3 subtype
PRJNA834136 | ENA
TranscriptomicsData set for "Gene Expression Profiles in Benign Prostate Tissue Reflect Tumor Proximity, Grade, and Molecular subtype
Background: Normal tissue in a tumor-bearing organ shows morphological and molecular differences from normal tissue in a tumor-free organ. One explanation to this is that tumors actively instruct adjacent normal tissues to support growth and invasion. The aim of this study was to examine if changes ...
ORGANISM(S): Homo sapiens 
2026-10-06 | E-MTAB-17721 | biostudies-arrayexpress
TranscriptomicsUndifferentiated pleomorphic sarcoma recapitulates the expressional profile of Subtype II Leiomyosarcoma
Background: Undifferentiated pleomorphic sarcoma (UPS), used to be called malignant fibrous histiocytoma (MFH), is a malignant soft tissue tumor of uncertain origin, and is characterized by morphology. UPS often share similar morphological characters with other sarcomas, especially Leiomyosarcoma. ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-53844 | biostudies-arrayexpress
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