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MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
ModelsCaravagna2010 - Tumour suppression by immune system
Tumour suppression by immune system through stochastic oscillations GiulioCaravagnaa Albertod’Onofriob PaoloMilazzoa RobertoBarbutia https://doi.org/10.1016/j.jtbi.2010.05.013 Abstract The well-known Kirschner–Panetta model for tumour–immune System interplay [Kirschner, D., Panetta, J.C., 1998. ...
2024-09-02 | BIOMD0000000912 | BioModels
Immuno-oncology 
ModelsKim2014 - Tumor model under immune suppression
its a mathematical model explaining the impact of chemotherapy and immunotherpay together on Tumor cells involving cytokines like Il2, IL10 and TGFbeta, immune cells like CD4+ T cells, CD8+ T cells, Memory T cells, NK cells, dendrtic cells. This model is based on the previous model published by Robe...
2019-09-25 | MODEL1909240002 | BioModels
Immuno-oncology 
MetabolomicsDual-Targeted Microspheres Reshape the Metabolic-immune Microenvironment and Reverse Multiple Dilemmas Post-embolization in Hepatocellular Carcinoma

Transarterial embolization (TAE) efficacy in hepatocellular carcinoma (HCC) is limited by post-embolization hypoxia-driven angiogenesis and metabolic reprogramming. To address these challenges, pH-responsive gelatin microspheres encapsulating zinc sulfide (ZnS) nanoparticles (ZnS@GMs) were develo...

2026-02-09 | MTBLS13720 | MetaboLights
TranscriptomicsTranscription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14941 | MetaboLights
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14943 | MetaboLights
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
TranscriptomicsDifferential Gene Expression of Soluble CD8+ T-cell mediated suppression of HIV replication in three older children
Goal: To compare the gene expression profiles from pediatric patients with each other, with those reported in adults and in those related to exosomes. Background: Suppression of human immunodeficiency virus (HIV) replication by CD8+ T-cells (CD8 suppression) contributes to survival in adults and chi...
ORGANISM(S): Homo sapiens 
2010-10-28 | E-GEOD-23183 | biostudies-arrayexpress
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