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MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
MetabolomicsButyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.

2026-06-26 | MTBLS14301 | MetaboLights
MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
MetabolomicsOperational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures (Cohort 2).
The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell transplantation from human leukocyte antigen-identical siblings. Primary tole...
2021-12-22 | MTBLS221 | MetaboLights
MetabolomicsOperational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures (Cohort 1).
The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell transplantation from human leukocyte antigen-identical siblings. Primary tole...
2021-12-22 | MTBLS220 | MetaboLights
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
MetabolomicsMulti-Omics Profiling Reveals Sex-Stratified Biomarkers Predicting Chronicity in Pediatric Primary Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is recognized as an acquired autoimmune hemorrhagic disorder distinguished by diminished platelet counts. The efficacy of a sex-stratified multi-omics integrative analytical strategy for forecasting pediatric ITP chronicity was proposed and validated in this ...

2025-09-01 | MTBLS12920 | MetaboLights
MetabolomicsMetabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights
TranscriptomicsRNA-seq analysis of PBMCs with TLR1-1805TT and TLR1-1805GG genotypes stimulated and restimulated (innate immune tolerance induction) with B. burgdorferi.
A TLR1 variant (1805GG) associated with severe Lyme disease may drive excessive inflammation. To investigate this, we stimulated (16hr) and restimulated (6hr) PBMCs from donors with or without TLR1-1805GG using Borrelia burgdorferi. Variant carriers showed stronger transcriptional and cytokine respo...
ORGANISM(S): Homo sapiens 
2025-11-13 | E-MTAB-16016 | biostudies-arrayexpress
MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
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