Immunomodulatory activity

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Unknown (2989)
Transcriptomics (400)
Genomics (293)
Proteomics (87)
Metabolomics (21)
Other (10)
Clinical (3)
Methylation profiling (3)
Models (1)
Multiomics (1)

Organisms

Homo sapiens (262)
Mus musculus (162)
Andropogon gerardi (44)
Bacteria (44)
Bartonella quintana JK 31 (44)
Rattus norvegicus (12)
Sus scrofa (4)
Bos taurus (3)
Canis lupus familiaris (3)
Streptococcus agalactiae (2)
Gallus gallus (2)
Danio rerio (2)
Arabidopsis thaliana (2)
Salmo salar (2)
Equus caballus (2)
Fusarium oxysporum (1)
Bifidobacterium bifidum (1)
Pan paniscus (1)
Macaca fascicularis (1)
Schistosoma mansoni (1)
Zea mays (1)
Aspergillus fumigatus Af293 (1)
mixed sample (1)
Solanum lycopersicum (1)
Mycobacterium tuberculosis H37Rv (1)
Ovis aries (1)
Drosophila melanogaster (1)
Cnaphalocrocis medinalis (1)
Oryza sativa Japonica Group (1)
Sinohyriopsis cumingii (1)

Organisms

Homo sapiens (104)
Mus musculus (90)
Rattus norvegicus (5)
Canis lupus familiaris (3)
Equus caballus (2)
Bifidobacterium longum (2)
Cordyceps militaris CM-whu (1)
Phocaeicola vulgatus PC510 (1)
rabbit gut metagenome (1)
Limosilactobacillus mucosae (1)
Salmo salar (1)
Lactococcus cremoris (1)
Drosophila melanogaster (1)
Ovis aries (1)
mouse gut metagenome (1)

Repository

ENA (262)
biostudies-arrayexpress (242)
geo (195)
pride (44)
MetaboLights (20)
iProX (15)
jPOST (14)
MassIVE (13)
EGA (7)
BioModels (1)
MetabolomicsWorkbench (1)
PanoramaPublic (1)

Tissue

Cell culture (14)
Blood cell (3)
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Fibroblast (3)
Liver (3)
Saliva (3)
Spleen (3)
B cell (2)
Brain (2)
Macrophage (2)
T cell (2)
Peritoneal fluid (1)
Blood (1)
Bone marrow (1)
Cell suspension culture (1)
Colon (1)
Dendritic cell (1)
Early embryonic cell (1)
Kidney (1)
Leaf (1)
MEF cell (1)
Mammary epithelial cell (1)
Mammary gland epithelial cell (1)
Mesenchymal cell (1)
Microglial cell (1)
Permanent cell line cell (1)
Primary cell (1)
Skin (1)
Small intestine mucosa (1)
Stem cell (1)

Disease

Acute leukemia (2)
Lymphoma (2)
Ewing family tumor (1)
Breast Neoplasms (1)
Carcinoma, Renal Cell (1)
Colorectal Neoplasms (1)
Sepsis (1)
Brain cancer (1)
COVID-19 (1)
Disease free (1)
Graft-versus-host disease (1)
Hepatocellular carcinoma (1)
Multiple myeloma (1)
Parasitic helminthiasis infectious disease (1)
Pertussis (1)

Technology Type

Mass Spectrometry (45)
Shotgun proteomics (23)
Bottom-up proteomics (11)
Mass spectrometry (10)
Mass spectrometry assay (10)
Data-dependent acquisition (7)
Data-independent acquisition (3)
Top-down proteomics (3)
Affinity purification coupled with mass spectrometry proteomics (2)
Illumina HiSeq 2500, Illumina HiSeq 4000, ILLUMINA (1)
ESI (1)
Affinity proteomics (1)
Gel-based experiment (1)
HDMSE (1)
Proteogenomics (1)

Instrument Platform

Illumina NovaSeq 6000 (19)
Illumina NovaSeq X (7)
Illumina HiSeq 2500 (7)
NextSeq 500 (6)
10x Chromium (4)
NextSeq 550 (4)
Illumina HiSeq 4000 (4)
N/A (2)
NextSeq 2000 (2)
Illumina HiSeq 1000 (2)
Illumina HiSeq 1500 (2)
Illumina HiSeq 2000 (2)
Chromium Next GEM Chip G (1)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (1)
Dr. Tom Multi-omics Data Mining System (1)
Animal Experiment Facility (1)
SPF Animal Room (1)
PCR Thermocycler, Fragment Analyzer (1)
Centrifuge, Nucleic Acid Quantification Instrument (1)
Biosafety Cabinet, Liquid Nitrogen Tank, -80°C Freezer (1)
Described in protocol (1)
BGI (1)
Affymetrix GeneChip (1)
Genomics Core Shared Resources at Augusta University (RRID: SCR_026483) (1)
RNeasy Mini Kit (Qiagen) (1)
GentleMACS Octo Dissociator with Heaters (Miltenyi Biotec, Cat. No. 130-096-427) together with the Human Tumor Dissociation Kit (Miltenyi Biotec, Cat. No. 130-095-929), (1)
Next GEM Single Cell 3' Gel Bead kit v3.1 (1)
Chromium Nuclei Isolation kit (10x Genomics 1000493) (1)
PromethION (1)
10X Genomics Chromium (1)

Publication Date

2026 (70)
2025 (63)
2024 (56)
2023 (50)
2021 (37)
2014 (34)
2011 (27)
2010 (24)
2022 (23)
2013 (22)
2012 (18)
2019 (17)
2016 (17)
2015 (17)
2008 (15)
2017 (10)
2009 (10)
2020 (9)
2018 (9)
2007 (4)
2006 (1)
2005 (1)

CHEBI ID

CHEBI:16765 (4)
CHEBI:27897 (4)
CHEBI:28238 (3)
CHEBI:16675 (3)
CHEBI:28790 (3)
CHEBI:16796 (3)
CHEBI:10072 (3)
CHEBI:18344 (3)
CHEBI:89825 (2)
CHEBI:59783 (2)
CHEBI:81244 (2)
CHEBI:22660 (2)
CHEBI:28171 (2)
CHEBI:28834 (2)
CHEBI:15793 (2)
CHEBI:28747 (2)
CHEBI:36259 (2)
CHEBI:17697 (2)
CHEBI:28683 (2)
CHEBI:17822 (2)
CHEBI:15428 (2)
CHEBI:16449 (2)
CHEBI:27266 (2)
CHEBI:28044 (2)
CHEBI:16811 (2)
CHEBI:30768 (2)
CHEBI:16135 (2)
CHEBI:43355 (2)
CHEBI:30746 (2)
CHEBI:27389 (2)

Metabolite Name

Naringenin (5)
Taurine (5)
3-Hydroxybutyric acid (5)
Tetradecanedioic acid (5)
Genistein (5)
Uridine (5)
Bilirubin (5)
Corticosterone (4)
8Z,11Z,14Z-Eicosatrienoic acid (4)
Taurochenodeoxycholic acid (4)
4-Pyridoxic acid (4)
Allantoin (4)
Serotonin (4)
Nicotinamide (4)
Indole (4)
N-Acetyl-L-tyrosine (4)
Taurocholic acid (4)
12-Hydroxydodecanoic acid (4)
16-Hydroxyhexadecanoic acid (4)
Deoxycholic acid (4)
Arachidonic acid (4)
Sebacic acid (4)
Cytosine (4)
Xanthosine (4)
Suberic acid (4)
L-Glutamine (4)
Adenine (4)
Biotin (4)
Creatinine (4)
Creatine (4)

First Public Date

2026 (55)
2025 (46)
2024 (40)
2023 (32)
2022 (21)
2021 (17)
2014 (14)
2019 (11)
2020 (9)
2017 (7)
2015 (4)
2016 (3)
2018 (2)
2013 (1)

Study status

Completed (2)
Not provided (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
AG Proteomics & Bioanalytics Institut für Experimentelle Medizin Christian-Albrechts-Universität zu Kiel 24105 Kiel, Germany (1)
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan (1)
All India Institute of Medical Sciences, New Delhi, India (1)
Biogen Inc., 225 Binney St, Cambridge, MA 02142, USA; Laboratory of Inflammation Research, School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang, Gyeongbuk 37554, Republic of Korea (1)
Bioiberica S.A.U., Av. Països Catalans 34, 08950 Esplugues de Llobregat, Barcelona, Spain (1)
Biomedical Research Novartis Pharma AG (1)
CRUK - Scotland Institute - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Chair of Drug and Cosmetics Biotechnology, Warsaw University of Technology, Warsaw, Poland (1)
Chair of protomeics and bioanalytics, Technical University of Munich, Freising, Germany (1)
Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (1)
Department of Biochemistry, Escola Paulista de Medicina, Federal University of São Paulo, (EPM/UNIFESP), São Paulo, SP, Brazil. (1)
Department of Chemistry, The Scripps Research Institute (1)
Department of Laboratory Medicine and Advanced Biotechnologies, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS - ISMETT) Via Ernesto Tricomi, 5 - 90127 Palermo (1)
Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia (1)
Department of Oral Biology and Pathology, Faculty of Odontology, Malmo University, Malmo, Sweden (1)
Department of Oral Biology and Pathology, Faculty of Odontology, Malmö University, Malmö, Sweden (1)
Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA (1)
Department of Pathology, UAMS, Little Rock, AR, USA 2 The Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA (1)
Department of Zoology, School of Natural Sciences, National University of Ireland, Galway. (1)
Fernando Garcia Martinez Ph.D. Proteomics & MS Specialist Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 (1)
Institute for Biology-Microbiology Freie Universität Berlin Königin-Luise-Strasse 12-16 D-14195 Berlin Germany (1)
Institute of Biomedical Chemistry (1)
Institute of Microbiology of the Czech Academy of Sciences, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic (1)
Institute of Parasitology, Centre for Biology, Academy of Science of the Czech Republic, Czech Republic Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic (1)
Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China (1)
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, China (1)
Malaga University, Institute of Blue Biotechnology and Development (IBYDA), Department of Ecology and Geology, Malaga, Spain (1)
Medical University of Warsaw, Head of Laboratory for Cell Research and Application (1)
Molecular Proteomics Laboratory, Biological Medical Research Centre, Heinrich Heine University, 40225 Düsseldorf, Germany (1)

Keyword

Immunomodulation (2)
Bayesian logistic regression model (2)
TNBC (2)
Biomarkers (2)
Spartalizumab (2)
PDR001 (2)
CRC (2)
Nazartinib (1)
Metastatic adenocarcinoma (1)
Large intestine (1)
Large intestine cancer (1)
Colorectum cancer (1)
Triple-negative breast cancer (TNBC) (1)
TNBC, basal type (1)
Secretory cell (1)
Adenoid cystic (1)
Medullary (1)
Ductal carcinoma (1)
Inflammatory (1)
Breast carcinoma (1)
Breast lump (1)
Pagets disease (1)
HER2 positive metastatic breast cancer (1)
Breast cancer positive for human epidermal growth factor receptor 2 (HER2) (1)
Breast cancer progression (1)
Estrogen-receptor (ER) positive(+) breast cancer (1)
Non-small cell lung carcinoma (NSCLC) (1)
Treatment of lung cancer after first metastasis (1)
Squamous cell lung carcinoma (1)
Large-cell lung carcinoma (1)

IsPrivate

False (1)

Submitter Keywords

Immuno-oncology (1)

Modification

N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (160)
RNA-seq of coding RNA (32)
RNA-seq of coding RNA from single cells (17)
RNA-seq of total RNA (5)
Methylation profiling by array (4)
Transcription profiling by RT-PCR (3)
Single nucleus RNA sequencing (3)
ChIP-seq (3)
Interventional (3)
Human - Single-cell sequencing (2)
Human - One-color microarray (2)
Comparative genomic hybridization by array (2)
Baseline (1)
Unknown experiment type (1)
Cell line - High-throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
ScATAC-seq (1)
MicroRNA profiling by array (1)
Genotyping by high throughput sequencing (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (420)
2022 (378)
2023 (368)
2021 (368)
2020 (265)
2024 (254)
2019 (202)
2018 (147)
2017 (141)
2014 (119)
2016 (104)
2015 (103)
2026 (86)
2013 (64)
2011 (48)
2012 (45)
2010 (42)
2008 (27)
2009 (25)
2007 (5)
2006 (5)
2005 (4)
2003 (4)
2004 (2)
2000 (2)
2002 (1)
2001 (1)
1998 (1)

Location

Taiwan (2)
Spain (2)
United States (2)
Singapore (1)
Egypt (1)
South Korea (1)
Germany (1)
Israel (1)
Italy (1)
Canada (1)
Netherlands (1)
United Kingdom (1)
France (1)
Belgium (1)

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Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation

Not available

ORGANISM(S): Mus musculus

ST001255 | MetabolomicsWorkbench

Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...

2023-05-02 | MTBLS5288 | MetaboLights

Immunomodulatory Activity of Flagellin on Human Respiratory Epithelium

PRJNA1298854 | ENA

Immunomodulatory, antioxidant, and potential anticancer activity of the polysaccharides of the fungus Fomitiporia chilensis

Fomitiporia species have aroused the interest of numerous investigations that reveal their biological activity and medicinal potential. The present investigation shows the antioxi-dant, anticancer, and immunomodulatory activity of acidic polysaccharides obtained from the fungus Fomitiporia chilensis...

ORGANISM(S): Homo sapiens (Human)

2024-10-17 | PXD048361 | Pride

Antioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs

The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy human gingival fibroblast cell lines (HGF-1), obtaining an IC50 of 228.66 µg mL...

ORGANISM(S): Homo sapiens (Human)

2022-12-21 | PXD029076 | Pride

Tmt-2plex. Sulfated polysaccharides Anticancer capacity Nutraceuticals Euglena gracilis Immunomodulatory capacity Antioxidant activity

Modulation of immunomodulatory peptide activity by 2-deoxy-d-glucose

The goal of this study was to identify the role of glycolysis in the activity of immunomodulatory peptides with respect to macrophage function using the glycolytic inhibitor 2-deoxy-d-glucose

ORGANISM(S): Homo sapiens

2016-10-29 | GSE74508 | GEO

Role for ISGF3II in the Antiviral Activity of IFN-gamma

Type-I (e.g. IFN-alpha, IFN-beta) and type-II IFNs (IFN-gamma) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-gamma is thought to do so only through STAT1 homodimers while type-I IFNs act...

ORGANISM(S): Homo sapiens

2011-01-19 | E-GEOD-25113 | biostudies-arrayexpress

IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory Activity

PRJNA1151131 | ENA

Homo sapiens

Modulation of immunomodulatory peptide activity by 2-deoxy-d-glucose

PRJNA300622 | ENA

Extracts of Sida cordifolia contain polysaccharides possessing immunomodulatory activity and rosmarinic acid compounds with antibacterial activity.

Not available

S-EPMC8793188 | biostudies-literature

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3807 Results

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