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ProteomicsAntioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs
The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy human gingival fibroblast cell lines (HGF-1), obtaining an IC50 of 228.66 µg mL...
ORGANISM(S): Homo sapiens (Human) 
2022-12-21 | PXD029076 | Pride
Tmt-2plex. Sulfated polysaccharides Anticancer capacity Nutraceuticals Euglena gracilis Immunomodulatory capacity Antioxidant activity 
ProteomicsDetermining DNA-protein binding affinities and specificities from crude lysates using a combined SILAC/TMT labeling strategy
Gene expression is driven by the binding of transcription factors to regulatory elements in the genome, such as enhancers and promoters. A powerful technique to study DNA-protein interactions is affinity purification followed by mass spectrometry. Classic affinity purifications coupled to quantitati...
ORGANISM(S): Homo sapiens (Human) 
2023-10-08 | PXD041674 | Pride
Tmt Silac Dna pulldowns Paqman 
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
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