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ProteomicsMacrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is involved in neurogenesis and human cancers. However, the role of DCLK1 in atherosclerosis remains undefined. In this st...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD039083 | Pride
Lc-ms/ms 
GenomicsGene expression profiles of Dclk1+ and Dclk1- PDAC cells
Gene expression profiles of Dclk1+ and Dclk1- PDAC cells
PRJNA578683 | ENA
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
ProteomicsDCLK1 small extracellular vesicle proteome
Doublecortin-like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric cancer. Here we show that DCLK1 expression in the gastric cancer cell line MKN1 impacts EV biogenesis both quantitatively ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD021371 | Pride
Exosomes Proteomics Extracellular vesicles Migration Dclk1 
ProteomicsLiP-MS on DCLK1 Purified from HEK293 cells treated with DCLK1-IN-1
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD055350 | Pride
Chemical probe Lip-ms 
GenomicsMacrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
PRJNA915119 | ENA
TranscriptomicsDclk1+ mouse pancreatic progenitor cells
Dclk1 (Doublecortin like kinase-1) labels a rare population of long-lived and largely quiescent cells in the adult mouse pancreas. The expression of Dclk1+ vs Dclk1- pancreatic cells (mostly acinar) is observed.
ORGANISM(S): Mus musculus 
2016-04-11 | GSE74429 | GEO
TranscriptomicsGene expression profiles of Dclk1+ and Dclk1- PDAC cells
Doublecortin-like kinase 1 (Dclk1) is known as a cancer stem cell marker of pancreatic ductal adenocarcinoma (PDAC). But the functional evidence to define the stem cell activity of these cells within tumors has not been explored. We compared the gene expression profiles of Dclk1-positive and -negati...
ORGANISM(S): Mus musculus 
2020-10-20 | GSE139167 | GEO
GenomicsAdult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury
Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury
PRJNA656510 | ENA
GenomicsThe RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1
The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1
PRJNA1261940 | ENA
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