Immunomodulatory effects

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Unknown (5000)
Genomics (570)
Transcriptomics (458)
Proteomics (84)
Metabolomics (20)
Other (8)
Methylation profiling (5)
Clinical (3)
Models (2)
Genomic (2)

Organisms

Homo sapiens (250)
Mus musculus (214)
Rattus norvegicus (14)
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Gallus gallus (4)
Bos taurus (3)
Danio rerio (3)
Canis lupus familiaris (3)
Streptococcus agalactiae (2)
Oryctolagus cuniculus (2)
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Macaca mulatta (2)
Fusarium oxysporum (1)
Brucella abortus (1)
Schistosoma mansoni (1)
mixed sample (1)
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Arabidopsis thaliana (1)
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mouse gut metagenome (1)
Oncorhynchus mykiss (1)
Aedes aegypti (1)
Mesocricetus auratus (1)
Macaca fascicularis (1)
Cavia porcellus (1)
Drosophila melanogaster (1)
Parabacteroides goldsteinii DSM 19448 = WAL 12034 (1)
Sinohyriopsis cumingii (1)
Candida albicans (1)

Organisms

Mus musculus (176)
Homo sapiens (175)
Rattus norvegicus (11)
Salmo salar (6)
Gallus gallus (4)
Macaca mulatta (3)
Canis lupus familiaris (3)
Oryctolagus cuniculus (2)
mouse gut metagenome (2)
Bos taurus (2)
gut metagenome (2)
Sus scrofa (2)
metagenome (2)
Danio rerio (2)
Phocaeicola vulgatus PC510 (1)
Pholiota aurivella (1)
Sparus aurata (1)
Sarcophilus harrisii (1)
Oncorhynchus mykiss (1)
Lactococcus cremoris (1)
Propionibacterium freudenreichii (1)
Sus scrofa domesticus (1)
Mesocricetus auratus (1)
Cavia porcellus (1)
Macaca fascicularis (1)
Aedes aegypti (1)
fish gut metagenome (1)
Drosophila melanogaster (1)
feces metagenome (1)
Lactiplantibacillus plantarum (1)

Repository

ENA (541)
geo (368)
biostudies-arrayexpress (128)
pride (56)
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Tissue

Cell culture (14)
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Blood (3)
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Heart (3)
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Umbilical cord (2)
Abdominal aorta (1)
B cell (1)
Bone marrow (1)
Cerebral cortex (1)
Colon (1)
Culture fluid (1)
Endothelial cell (1)
MEF cell (1)

Disease

Disease free (4)
Wounds and Injuries (3)
Colorectal Neoplasms (2)
Bacterial sepsis (2)
Graft-versus-host disease (2)
Lymphoma (2)
Ewing family tumor (1)
Intestinal Neoplasms (1)
Abdominal aorta artery (1)
Autism spectrum disorder (1)
Brain ischemia (1)
COVID-19 (1)
Chronic myelogenous leukemia (1)
Colon cancer (1)
Inflammation (1)
Liver cancer (1)
Neuroblastoma (1)
Non-small cell lung carcinoma (1)
Parasitic helminthiasis infectious disease (1)
Severe acute respiratory syndrome (1)

Technology Type

Mass Spectrometry (56)
Shotgun proteomics (25)
Bottom-up proteomics (19)
Mass spectrometry assay (11)
Mass spectrometry (9)
Data-dependent acquisition (8)
Data-independent acquisition (7)
Gel-based experiment (3)
SWATH MS (3)
Affinity purification coupled with mass spectrometry proteomics (2)
Affinity proteomics (1)
HDMSE (1)
Olink affinity proteomics (1)
Proteogenomics (1)

Instrument Platform

Illumina NovaSeq 6000 (10)
Illumina HiSeq 2500 (4)
Illumina NovaSeq X (3)
NextSeq 500 (3)
Illumina HiSeq 1500 (2)
TimsTOF Pro (2)
Chromium Next GEM Chip G (1)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (1)
Dr. Tom Multi-omics Data Mining System (1)
Animal Experiment Facility (1)
SPF Animal Room (1)
PCR Thermocycler, Fragment Analyzer (1)
Centrifuge, Nucleic Acid Quantification Instrument (1)
Biosafety Cabinet, Liquid Nitrogen Tank, -80°C Freezer (1)
Described in protocol (1)
Genomics Core Shared Resources at Augusta University (RRID: SCR_026483) (1)
RNeasy Mini Kit (Qiagen) (1)
GentleMACS Octo Dissociator with Heaters (Miltenyi Biotec, Cat. No. 130-096-427) together with the Human Tumor Dissociation Kit (Miltenyi Biotec, Cat. No. 130-095-929), (1)
Next GEM Single Cell 3' Gel Bead kit v3.1 (1)
Chromium Nuclei Isolation kit (10x Genomics 1000493) (1)
Affymetrix Gene Titan (1)
Gene Titan (1)
N/A (1)
DNBSEQ-T7 (1)
NextSeq 550 (1)
Illumina HiSeq 4000 (1)
LTQ Orbitrap XL ETD (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion Lumos (1)
Q Exactive HF (1)

Publication Date

2025 (112)
2026 (106)
2024 (73)
2023 (53)
2022 (36)
2021 (33)
2010 (24)
2011 (21)
2014 (18)
2019 (15)
2020 (14)
2013 (14)
2015 (13)
2018 (11)
2016 (11)
2012 (11)
2017 (10)
2009 (10)
2008 (8)
2007 (7)
2006 (1)
2005 (1)

CHEBI ID

CHEBI:16264 (3)
CHEBI:16708 (2)
CHEBI:16610 (2)
CHEBI:27823 (2)
CHEBI:29016 (2)
CHEBI:16704 (2)
CHEBI:32805 (2)
CHEBI:48153 (2)
CHEBI:15682 (2)
CHEBI:27468 (2)
CHEBI:15843 (2)
CHEBI:15318 (2)
CHEBI:15741 (2)
CHEBI:16467 (2)
CHEBI:16750 (2)
CHEBI:17858 (2)
CHEBI:17345 (2)
CHEBI:16027 (2)
CHEBI:16335 (2)
CHEBI:16675 (2)
CHEBI:16919 (2)
CHEBI:17645 (2)
CHEBI:15603 (2)
CHEBI:17596 (2)
CHEBI:15756 (2)
CHEBI:17368 (2)
CHEBI:30769 (2)
CHEBI:193326 (1)
CHEBI:181855 (1)
CHEBI:182145 (1)

Metabolite Name

3-Hydroxybutyric acid (6)
Naringenin (5)
Genistein (5)
Allantoin (5)
Taurine (5)
Xanthosine (5)
Sebacic acid (5)
Tetradecanedioic acid (5)
Uridine (5)
Bilirubin (5)
8Z,11Z,14Z-Eicosatrienoic acid (4)
Taurochenodeoxycholic acid (4)
Corticosterone (4)
2'-Deoxyuridine (4)
Orotic acid (4)
4-Pyridoxic acid (4)
3-Methylxanthine (4)
Nicotinamide (4)
N-Acetyl-L-tyrosine (4)
Taurocholic acid (4)
12-Hydroxydodecanoic acid (4)
16-Hydroxyhexadecanoic acid (4)
Deoxycholic acid (4)
Monobutyl phthalate (4)
Pentadecanoic acid (4)
Arachidonic acid (4)
Mesaconic acid (4)
Cytosine (4)
Suberic acid (4)
Palmitic acid (4)

First Public Date

2026 (128)
2025 (121)
2024 (77)
2023 (42)
2022 (40)
2021 (35)
2014 (29)
2020 (19)
2019 (16)
2018 (12)
2015 (9)
2017 (8)
2016 (4)
2013 (1)

Modelling Approach

Differential equation model (1)

Study status

Not provided (1)
Recruiting (1)
Completed (1)

Lab affiliation

All India Institute of Medical Sciences, New Delhi, India (2)
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Infection Medicine, Lund, Sweden (2)
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal. (2)
School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland (2)
Aarhus University (1)
Australian Institute of Tropical Health and Medicine. Centre for Molecular Therapeutics. James Cook Univerisity, Cairns. (1)
Berlin Insitute of Health, Proteomics Platform, Charité University Medicine, Berlin, Germany (1)
Biogen Inc., 225 Binney St, Cambridge, MA 02142, USA; Laboratory of Inflammation Research, School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang, Gyeongbuk 37554, Republic of Korea (1)
CRUK - Scotland Institute - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Center for Regeneration and Aging,BGI-haangzhou (1)
Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081 (1)
Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (1)
Department of Animal Sciences, Faculty of BIOVIT, Norwegian University of Life Sciences, Ås, Norway (1)
Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece (1)
Department of Biochemistry, Escola Paulista de Medicina, Federal University of São Paulo, (EPM/UNIFESP), São Paulo, SP, Brazil. (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
Department of Molecular Cell Biology, Weizmann Institute of Science (1)
Department of Molecular Hematology, Sanquin Research, Amsterdam, the Netherlands (1)
Department of Oral Biology and Pathology, Faculty of Odontology, Malmo University, Malmo, Sweden (1)
Department of Oral Biology and Pathology, Faculty of Odontology, Malmö University, Malmö, Sweden (1)
Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States (1)
Department of Radiology Perelman School of Medicine at the University of Pennsylvania (1)
Department of Surgery Hollings Cancer Center (HO 512H) Medical University of South Carolina (1)
Department of Surgery, University of Florida, Gainesville, FL, USA; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida, Gainesville, FL, USA (1)
Gonçalo Moniz Institute, FIOCRUZ, Salvador, Brazil D'Or Institute for Research and Education (IDOR), Salvador, Brazil Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil (1)
Immunopathology of Virus Infections Institute of Virology Technical University of Munich (1)
Institute of Microbiology, Department of Microbial Proteomics, Center for Functional Genomics of Microbes, University of Greifswald, 17489 Greifswald, Germany (1)
Instituto de Medicina Molecular Aplicada-Nemesio Díez (IMMA-ND) Edificio EPS, Despacho 1.1.3. Universidad San Pablo CEU. Campus Montepríncipe. Crtra. Boadilla del Monte km 5.3. CP 28668 Boadilla del Monte. Madrid. (1)
Intercollegiate Faculty of Biotechnology University of Gdansk (1)
Korea Brain Research Institute (1)

Keyword

Statin (1)
CRC-Insulin (1)
ERAS (1)
Vemurafenib (1)
Simvastatin (1)
Colorectal (1)
Colon (1)
Cetuximab (1)

IsPrivate

False (2)

Submitter Keywords

Immuno-oncology (1)

Modification

Not available (1)

Study type

Transcription profiling by array (92)
RNA-seq of coding RNA (15)
RNA-seq of coding RNA from single cells (8)
Interventional (3)
Unknown experiment type (2)
Transcription profiling by RT-PCR (2)
Human - Single-cell sequencing (1)
Human - One-color microarray (1)
Cell line - High-throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
Comparative genomic hybridization by array (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (775)
2022 (665)
2021 (609)
2023 (608)
2024 (485)
2020 (442)
2019 (298)
2018 (212)
2017 (204)
2016 (152)
2015 (134)
2014 (121)
2026 (114)
2013 (71)
2011 (59)
2012 (58)
2010 (46)
2008 (23)
2009 (21)
2007 (8)
2006 (6)
2004 (5)
2005 (4)
2003 (4)
1998 (2)
2001 (1)
2000 (1)

Location

Saudi Arabia (1)
New Zealand (1)
China (1)

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Differentially manufactured Arnica montana L. extracts mediate anti-inflammatory effects on human T cells via different signaling pathways

Arnica montana L. (Arnica) has a long history of use in treating inflammation and soft tissue injury, yet its immunomodulatory mechanisms remain largely unexplored. In this study, we investigated the effects of distinct Arnica extracts - derived from different plant parts (root or whole ...

2025-09-16 | MTBLS11351 | MetaboLights

Multi-omics analysis reveals the modulatory effects of Moringa oleifera ethanol extract on gut microbiota and metabolic profiles in broilers

The overuse of antimicrobial growth promoters (AGPs) in poultry farming has raised global concerns about antimicrobial resistance and food safety, prompting the search for effective natural alternatives. Moringa is rich in bioactive compounds with antimicrobial and immunomodulatory properties; ho...

2026-08-04 | MTBLS15049 | MetaboLights

Immunomodulatory effects of ponesimod on human astrocytes

PRJNA720567 | ENA

Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung II

PRJNA813312 | ENA

Proteomic Insights into Aprotinin’s Immunomodulatory Effects in Attenuating Renal Fibrosis in a Unilateral Ureteral Obstruction Model

Chronic kidney disease (CKD) is characterized by progressive renal fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent effects on kidney function, but its role in chronic obstructive nephropathy remains unclear.

ORGANISM(S): Mus Musculus

2025-05-03 | PXD063655 |

Immunomodulatory effects of PI3Kδ inhibition in murine and human solid tumors [mouse]

PRJNA699479 | ENA

Immunomodulatory effects of PI3Kδ inhibition in murine and human solid tumors [human]

PRJNA699478 | ENA

Single-cell RNA sequencing analysis of baicalein’s immunomodulatory effects in lung graft ischemia-reperfusion injury

PRJNA1201256 | ENA

Immunomodulatory effects of microbiota-derived propionate in systemic lupus erythematosus

PRJNA1150989 | ENA

Immunomodulatory effects of vitamin D supplementation in a deficient population

PRJNA663404 | ENA