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UnknownEfficiently enhancing ferroptosis-mediated immunosensitization in lung cancer by an inhalable immune activation nanoplatform.
Not available
S-EPMC12681739 | biostudies-literature
UnknownAberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor.
Not available
S-EPMC3960761 | biostudies-literature
UnknownPan-cancer bone metastasis atlas at single-cell resolution identifies a distinct tumor-associated macrophage subset for mediating Denosumab-induced immunosensitization in lung cancer bone metastasis.
Not available
S-EPMC12681936 | biostudies-literature
TranscriptomicsRat models for Portosinusoidal Vascular Disease
Background: Porto-Sinusoidal Vascular Disorder (PSVD) involves a group of rare vascular liver diseases of unknown etiology that leads to the development of portal hypertension and its life-threatening complications. Its pathophysiology is not well understood and animal models described to date do no...
ORGANISM(S): Rattus norvegicus 
2024-03-14 | GSE229380 | GEO
TranscriptomicsImproved antitumor activity of immunotherapy combined with BRAF and MEK inhibitors in BRAFV600E mutant melanoma
The first clinical trial testing the combination of targeted therapy with a BRAF inhibitor vemurafenib and immunotherapy with a CTLA-4 antibody ipilimumab was terminated early due to significant liver toxicities, possibly due to paradoxical activation of the MAPK pathway by BRAF inhibitors in tumors...
ORGANISM(S): Mus musculus 
2014-12-12 | GSE64102 | GEO
TranscriptomicsImproved antitumor activity of immunotherapy combined with BRAF and MEK inhibitors in BRAFV600E mutant melanoma
The first clinical trial testing the combination of targeted therapy with a BRAF inhibitor vemurafenib and immunotherapy with a CTLA-4 antibody ipilimumab was terminated early due to significant liver toxicities, possibly due to paradoxical activation of the MAPK pathway by BRAF inhibitors in tumors...
ORGANISM(S): Mus musculus 
2014-12-12 | E-GEOD-64102 | biostudies-arrayexpress
ProteomicsTargeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Cyclin-Dependent Kinase 9 (CDK9) as part of the PTEFb complex promotes transcriptional elongation by promoting RNAPII pause release. We now report that, paradoxically, CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell screen, we discovered that CDK9 i...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD007925 | Pride
Cdk9 Epigenetic therapy Immunosensitization Gene silencing 
GenomicsMus musculus
Improved antitumor activity of immunotherapy combined with BRAF and MEK inhibitors in BRAFV600E mutant melanoma
PRJNA270119 | ENA
GenomicsRat models for Portosinusoidal Vascular Disease
Rat models for Portosinusoidal Vascular Disease
PRJNA954319 | ENA
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