Sort   by:  
 Page size 
MetabolomicsLiver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma

Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) ce...

2025-09-07 | MTBLS12950 | MetaboLights
MetabolomicsUPLC-QE-Orbitrap-MS-Based Metabolomics and Gut Microbiome Analysis to Reveal Codonopsis pilosula (Franch.) Nannf. Extract Improves Cyclophosphamide-Induced Immunosuppression in Mice

Immune system dysfunction leads to recurrent or severe infections, increased susceptibility to concurrent illnesses, and heightened risk of tumors. Current immunomodulators often carry side effects, whereas phytotherapy offers relative stability, making this therapeutic approach worthy of explora...

2026-02-03 | MTBLS13825 | MetaboLights
MetabolomicsSmall molecule signatures of mice lacking T-cell p38 alternate activation, a model for immunosuppression conditions, after exposure to total body radiation (part II)
Not available
ORGANISM(S): Mus musculus 
ST001892 | MetabolomicsWorkbench
MetabolomicsSmall molecule signatures of mice lacking T-cell p38 alternate activation, a model for immunosuppression conditions, after exposure to total body radiation (part I)
Not available
ORGANISM(S): Mus musculus 
ST001891 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human liver transplant patients reveals a signature that could discriminate tolerant recipients from immunosuppression-dependent patients
mmunosuppressive drugs can be completely withdrawn in up to 20% of liver transplant recipients, commonly referred to as ‘operationally’ tolerant. Immune characterization of these patients, however, has not been performed in detail, and we lack tests capable of identifying tolerant patients among...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11881 | biostudies-arrayexpress
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
ModelsShariatpanahi2018 - Mathematical modeling of tumor-induced immunosuppression by myeloid-derived suppressor cells
This is a ODE-based mathematical model featuring equations describing the dynamics of tumor cells, cytotoxic T cells, natural killer cells, and myeloid-derived suppressor cells (MDSCs) that together describe the tumor-induced immunosuppression caused by MDSCs.
2019-09-09 | MODEL1909090003 | BioModels
Immuno-oncology 
TranscriptomicsMolecular Characterization of Acute Cellular Rejection Occurring during Intentional Immunosuppression Withdrawal in Liver Transplantation
Acute cellular rejection occurs frequently during the first few weeks following liver transplantation. During this period its molecular phenotype is confounded by pro-inflammatory events elicited by surgery, ischemia-reperfusion injury and early post-transplant complications. To unambiguously define...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-70305 | biostudies-arrayexpress
GenomicsTargeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
EGAS00001006334 | EGA
TranscriptomicsTranscriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...
ORGANISM(S): Danio rerio 
2022-02-25 | E-MTAB-11092 | biostudies-arrayexpress
Sort   by:  
 Page size