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GenomicsDNA Methylation in IMR90 cells
DNA methylation was measured by MBD2 enrichment of DNA fragments in IMR90. A statistical model was developed to estimate absolute methylation levels, and compared to whole genome bisulfite sequencing results (Lister, R. et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38679 | biostudies-arrayexpress
GenomicsTranscriptomics of human IMR90 model of replicative senescence
Transcriptomics of human IMR90 model of replicative senescence
PRJEB101881 | ENA
GenomicsGenome-wide profiling of H3K27ac (ChIP-seq) in IMR90 cells
To determine the genome-wide pattern of H3K27ac in IMR90 (ATCC CCL-186) cells we performed ChIP-seq upon hormone treatment (1.5 h, 1 M dexamethasone).
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5355 | biostudies-arrayexpress
TranscriptomicsIMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-18760 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of human IMR90 model of replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. We employ transcriptomics (alongside proteomics) to determine changes at the mRNA and protein levels, ...
ORGANISM(S): Homo sapiens 
2026-07-16 | E-MTAB-15914 | biostudies-arrayexpress
TranscriptomicsExpression data from ER32 and ER32.40HT IMR90
IMR90 cells were infected with pLNC-RAS:ER (from Jesus Gil lab) with retroviral gene transfer. Infected cells were drug selected G418. The cells were induced either with ethanol as control or with 100nM final conc 4-hydroxytamoxifen (sigma H7904) for ectopic expression of protein We used RNA-Seq to ...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-52848 | biostudies-arrayexpress
GenomicsBulk RNA-seq of IMR90 cell replicative senescence
Bulk RNA-seq of IMR90 cell replicative senescence
PRJNA1526117 | ENA
TranscriptomicsChanges in gene expression of Imr90 cells with age and senescence under 3% and 20% oxygen growth conditions
Senescent is an irreversible form of cell cycle arrest initiated by damaged cell constituents and subsequent pro-oncogenic signaling. Replicative senescence in vitro can be considered a model for human aging. When fibroblasts are cultured under atmospheric oxygen conditions of 20%, typical of norm...
ORGANISM(S): Homo sapiens 
2010-03-06 | E-GEOD-19018 | biostudies-arrayexpress
UnknownThe use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response.
Not available
S-EPMC4126993 | biostudies-literature
TranscriptomicsInvestigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells
The complexity and heterogeneity of cancer cells are under-represented by the current experimental models which revolve around primary tumor cells, cancer cell lines, and rodent models. We used the transformed cell model in our studies. IMR90 and BJ fibroblast cells were transformed by three oncogen...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-24097 | biostudies-arrayexpress
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