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ProteomicsDe novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography
Understanding molecular mechanisms of cellular pathways regularly requires knowledge of the identities of participating proteins, their cellular localization and their 3D structures. Contemporary workflows typically require multiple techniques to identify target proteins, track their localization us...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD036885 | Pride
Global protein abundance In situ cryoet Mouse sperm axoneme Sperm flagella Visual proteomics 
UnknownIn-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET.
Not available
S-EPMC11507944 | biostudies-literature
UnknownCryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging <i>in situ</i>.
Not available
S-EPMC12632634 | biostudies-literature
UnknownCellular electron cryo tomography and in situ sub-volume averaging reveal the context of microtubule-based processes.
Not available
S-EPMC5287354 | biostudies-literature
UnknownIn Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center.
Not available
S-EPMC8510550 | biostudies-literature
UnknownStructural dynamics of mitochondrial ATP synthase in <i>Chlamydomonas reinhardtii</i> revealed by <i>in situ</i> CryoET.
Not available
S-EPMC12458427 | biostudies-literature
UnknownCryoET of β-amyloid and tau within postmortem Alzheimer's disease brain.
Not available
S-EPMC11269202 | biostudies-literature
ProteomicsCryoEM-enabled visual proteomics reveals de novo structures of oligomeric protein complexes from Azotobacter vinelandii
Single particle cryoelectron microscopy (cryoEM) and cryoelectron tomography (cryoET) are powerful methods for unveiling unique and functionally relevant structural states. Aided by mass spectrometry and machine learning, they promise to facilitate the visual exploration of proteomes. Leveraging vis...
ORGANISM(S): Azotobacter vinelandii Bacteria 
2026-05-25 | PXD062624 | Pride
Nitrogen fixation Cryoet Visual proteomics Anerobic Cryoem 
ProteomicsCryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state
Translational control is an essential process for the cell to adapt to varying physiological or environmental conditions. To survive adverse conditions such as low nutrient levels, translation can be shut down almost entirely by inhibiting ribosomal function. Here we investigated eukaryotic hibernat...
ORGANISM(S): Spraguea lophii 42_110 
2025-12-01 | PXD044467 | Pride
Ribosome Spraguea lophii Microsporidia 
UnknownMPicker: visualizing and picking membrane proteins for cryo-electron tomography.
Not available
S-EPMC11707294 | biostudies-literature
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