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MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (MALDI imaging MS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS744 | MetaboLights
MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (UPLC-MS/MS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS746 | MetaboLights
MetabolomicsSpatial metabolomics of in situ, host-microbe interactions (On-tissue MALDI imaging MS/MS assay)
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defense molecules and chemical interactions in natural communities. Most current techniques are unable to spatially link the genotype and metabolic phenotype of microorganisms in situ at a ...
2019-11-15 | MTBLS805 | MetaboLights
GenomicsIn-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila
In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila
PRJNA1328808 | ENA
ProteomicsHuman alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells
Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells (iAT2s) have rapidly contributed to our understanding of AT2 function and disease. However, as iAT2s are primarily cultured in three-dimensional (3D) Matrigel, a matrix derived from cancerous mouse tissue, it i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-10 | MSV000091470 | MassIVE
MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
GenomicsMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
MALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
PRJNA1014120 | ENA
ProteomicsMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
Highly specialized cells are fundamental for proper functioning of complex organs. Variations in cell-type specific gene expression and protein composition have been linked to a variety of diseases. Although single cell technologies have emerged as valuable tools to address this cellular heterogenei...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044958 | Pride
Cellular heterogeneity Laser capture microdissection Imaging mass spectrometry Proteomics Data integration Dentate gyrus 
ProteomicsDeep-sea in situ and laboratory proteomics provide insights into the sulfur metabolism characteristics of a novel deep-sea bacterium, Pseudodesulfovibrio serpens sp. nov.
Sulfate-reducing bacteria (SRB) are ubiquitously distributed across various biospheres and play key roles in global sulfur and carbon cycles. However, few deep-sea SRB have been cultivated and studied in situ, limiting our understanding of the true metabolism of SRB in the deep biosphere. Here, we f...
ORGANISM(S): environmental samples <bacteria 
2026-02-23 | PXD043318 | Pride
Sulfate-reducing bacteria  cultivation  deep sea  sulfur metabolism  in situ  proteomics  metatranscriptomics 
ProteomicsDe novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography
Understanding molecular mechanisms of cellular pathways regularly requires knowledge of the identities of participating proteins, their cellular localization and their 3D structures. Contemporary workflows typically require multiple techniques to identify target proteins, track their localization us...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD036885 | Pride
Global protein abundance In situ cryoet Mouse sperm axoneme Sperm flagella Visual proteomics 
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