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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
ProteomicsProteomic profiling of human monocytes stimulated in vitro with N. meningitidis
Meningococcal sepsis is an overwhelming form of the sepsis syndrome which may cause mortality within 12-24 hours in previously healthy children and adults, where the causative infectious agent is N. meningitidis, an obligate human pathogen. The genomic changes induced by N. meningitidis are modulate...
ORGANISM(S): Homo sapiens 
2017-12-15 | E-MTAB-4795 | biostudies-arrayexpress
ProteomicsProteomic analysis of phosphorylation sites in rice panicle grain number-related proteins
The in vitro purified protein was used to detect the phosphorylation sites of substrates by kinases.
ORGANISM(S): Oryza sativa (Rice) 
2025-09-09 | PXD064053 | Pride
Phosphorylation sites ，rice，lc-msms 
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
ProteomicsKv7.2 LC-MSMS - Updating in vivo and in vitro phosphorylation and methylation sites of voltage-gated Kv7
Voltage-gated Kv7.2 potassium channels regulate neuronal excitability. The gating of Kv7 channels is regulated by various mediators and neurotransmitters acting via G protein-coupled receptors; the underlying signalling cascades involve phosphatidylinositol-4,5-bisphosphate (PIP2), Ca2+/Calmodulin a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2017-08-25 | PXD005567 | Pride
Methylation Kv7.2 Phosphorylation Kcnq2 
TranscriptomicsExpression data from P14 TCR cytotoxic T cells overexpressing HDAC7 phosphorylation deficient mutant
The present study reports an unbiased analysis of the cytotoxic T cell serine-threonine phosphoproteome using high resolution mass spectrometry. Approximately 2,000 phosphorylations were identified in CTLs of which approximately 450 were controlled by TCR signaling. A significantly overrepresented g...
ORGANISM(S): Mus musculus 
2011-03-13 | E-GEOD-27092 | biostudies-arrayexpress
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080218 | MassIVE
ProteomicsAnalysis of EYA3 phosphorylation by Src kinase
Data-dependent nLC-MS/MS analysis of EYA3 phosphorylation by Src protein tyrosine kinase
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD016526 | Pride
Tyrosine phosphorylation Eya3 Nlc-ms/ms Src 
ProteomicsIdentification of Aurora B phosphorylation mediated by KAT2A-treated PGK1 in vitro
The dataset was generated to characterize Aurora B phosphorylation following the KAT2A-PGK1 in vitro reaction.
ORGANISM(S): Homo sapiens (Human) 
2026-09-04 | PXD083647 | Pride
Human  hepatocellular carcinoma  hcc  lactate  protein lactylation  lysine lactylation  pgk1  k131  immunoprecipitation  lc-ms/ms  pgk1  aurora b  aurkb  kat2a  lactylation  phosphorylation 
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