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MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
MetabolomicsSafety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
2026-04-29 | MTBLS14408 | MetaboLights
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsIn Vivo CRISPR Screens Identify SLC1A5 as a Metabolic Barrier for Cancer Immunotherapy
Tumor metabolic reprogramming profoundly shapes antitumor immunity, but the mechanisms linking glutamine metabolism to immune evasion in hepatocellular carcinoma (HCC) remain incompletely understood. Here, we identify the glutamine transporter SLC1A5 as a tumor-intrinsic regulator of HCC progression...
2026-08-20 | MTBLS15401 | MetaboLights
TranscriptomicsLuminal-like and basal-like in vivo breast cancer xenograft models
The number of relevant and well-characterized cell lines and xenograft models for studying human breast cancer are few, and may represent a limitation for this field of research. With the aim of developing new breast cancer model systems for in vivo studies of hormone dependent and independent tumor...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-23041 | biostudies-arrayexpress
MetabolomicsMetabolic phenotyping of ex-vivo breast samples by DESI mass spectrometry imaging
This study involves the analysis of surgically resected samples from patients undergoing breast surgery. The samples published here have been used as part of the publication by [1], and all experimental details can be found within. Desorption electrospray ionisation mass spectrometry imaging (DESI M...
2016-04-28 | MTBLS273 | MetaboLights
TranscriptomicsModeling tumor subtypes in vivo using lineage restricted transgenic shRNA
Expression analysis from two genetically engineered mouse models of osteosarcoma determine the expression profile of mouse osteosarcoma Human osteosarcoma (OS) is comprised of three different subtypes: fibroblastic, chondroblastic and osteoblastic. We previously generated a mouse model of fibroblast...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-38742 | biostudies-arrayexpress
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsLNCaP Atlas: Gene expression associated with in vivo progression to castration-recurrent prostate cancer
Background: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. Methods: We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC in vivo using replicate LongSAGE libraries. We refer ...
ORGANISM(S): Homo sapiens 
2010-09-26 | E-GEOD-18402 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of bovine in vivo pre-implantation development
During mammalian pre-implantation embryonic development dramatic and orchestrated changes occur in gene transcription. The identification of the complete changes has not been possible until the development of the Next Generation Sequencing Technology. Here we report the first transcriptome dynamics...
ORGANISM(S): Bos taurus 
2014-09-10 | E-GEOD-59186 | biostudies-arrayexpress
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