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MetabolomicsMonitoring recombinant protein expression in bacteria by rapid evaporative ionisation mass spectrometry

RATIONALE: There is increasing interest in methods of direct analysis mass spectrometry that bypass complex sample preparation steps.

METHODS: One of the most interesting new ionisation methods is rapid evaporative ionisation mass spectrometry (REIMS) in wh...

2022-01-28 | MTBLS957 | MetaboLights
TranscriptomicsGene Expression and Comparative Genomic Hybridization of Ductal Carcinoma In Situ of the Breast
Background The dramatic increase in incidence of ductal carcinoma in situ (DCIS) associated with mammographic screening for breast cancer has given emphasis to the challenges of managing this important clinical entity. Unlike invasive breast cancer, there is no established histopathologic grading sy...
ORGANISM(S): Homo sapiens 
2008-11-24 | E-GEOD-7882 | biostudies-arrayexpress
TranscriptomicsDifferentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer
This SuperSeries is composed of the following subset Series: GSE41194: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 1) GSE41196: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive...
ORGANISM(S): Homo sapiens 
2012-09-29 | E-GEOD-41228 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human urinary superficial transitional cell carcinoma with surrounding carcinoma in situ (CIS) lesions, without surrounding CIS lesions, and muscle invasive carcinoma
The presence of carcinoma in situ (CIS) lesions in the urinary bladder is associated with a high risk of disease progression to a muscle invasive stage. In this study, we used microarray expression profiling to examine the gene expression patterns in superficial transitional cell carcinoma (sTCC) wi...
ORGANISM(S): Homo sapiens 
2007-11-28 | E-GEOD-3167 | biostudies-arrayexpress
Transcriptomicscis sequence effects on gene expression
Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence varia...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-8394 | biostudies-arrayexpress
TranscriptomicsSpatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization
Though important for gene regulation most studies of genome organisation use either fluorescence in situ hybridisation (FISH) or chromosome conformation capture (3C) methods. FISH directly visualises the spatial relationship of sequences, but is usually applied to a few loci at a time. The frequency...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-61814 | biostudies-arrayexpress
TranscriptomicsaCGH study of lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC)
The identification of lobular caricnoma in situ (LCIS) in a patient's specimen confers and appreciable increased risk of development of future invasive mammary carcinoma. However the study of LCIS presents a challenge as it is usually only recognized in fixed specimens and no good in vivo or in vitr...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-20474 | biostudies-arrayexpress
GenomicsGlobal temporal gene expression of Nematostella vectensis in-situ
Global temporal gene expression of Nematostella vectensis in-situ
PRJNA601911 | ENA
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (gene expression)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42669 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomic analyses of triple negative and luminal A breast ductal carcinoma in situ
This experiment includes GeoMx spatial transcriptomic analyses of FFPE tissue from breast ductal carcinoma in situ lesions from 16 patients. All lesions were subject to ER, PR, HER2 and Ki67 immunohistochemistry and assigned a molecular subtype. The main aim was to compare DCIS of the two subtypes T...
ORGANISM(S): Homo sapiens 
2026-06-26 | E-MTAB-16918 | biostudies-arrayexpress
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