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MetabolomicsLION-web validation lipidomics experiments (FA-incorporation, membrane fluidty)
A major challenge for lipidomic analyses is the handling of the large amounts of data and the translation of results to interpret the involvement of lipids in biological systems. We built a new lipid ontology (LION) that associates over 50,000 lipid species to biophysical, chemical and cell biologic...
2019-04-24 | MTBLS757 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres
This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35524 | biostudies-arrayexpress
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
TranscriptomicsCell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast
Acetylation of histone H3 lysine 56 is a covalent modification best-known as a mark of newly-replicated chromatin, but has also been linked to replication-independent histone replacement. Here, we measured H3K56ac levels at single-nucleosome resolution in asynchronously growing yeast cultures, as w...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-03 | E-GEOD-12822 | biostudies-arrayexpress
TranscriptomicsTelomeric repeats facilitate CENP-A incorporation via telomere binding proteins
The histone H3 variant, CENP-ACnp1, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined. To explore the tolerances and constraints on CENP-ACnp1 depositio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-08-22 | E-GEOD-46427 | biostudies-arrayexpress
ProteomicsRecoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids
Expanding the genetic code has revolutionized our ability to study and manipulate biological systems through site-specific incorporation of noncanonical amino acids (ncAAs). However, current methods are primarily limited to single-type ncAA incorporation in mammalian cells owing to translation ineff...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070277 |
ProteomicsSite-specific incorporation of two noncanonical amino acids in GFP
Site-specific incorporation of two noncanonical amino acids for two-color bioorthogonal labeling and chemical-controlled crosslinking of proteins on live mammalian cells
ORGANISM(S): Mus Musculus (mouse) 
2020-06-11 | PXD019411 | JPOST Repository
ProteomicsTMPRSS2-induced Golgi disruption restricts the incorporation of virus envelope glycoproteins into virions
Understanding the relationship between viral proteins and host factors is essential for developing strategies to control virus infections. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells using angiotensin converting enzyme 2 (ACE2) and transmembrane protease, serine 2...
ORGANISM(S): Homo Sapiens (human) 
2026-04-15 | PXD065094 | JPOST Repository
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