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TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsExpression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28365 | biostudies-arrayexpress
TranscriptomicsThe Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons
We have assessed the importance of SQSTM1 in human induced pluripotent stem cell (iPSC)-derived cortical neurons with and without SQSTM1. By combining high-content imaging, RNA-Seq, and functional mitochondrial readouts, we showed that SQSTM1 depletion causes aberrations in mitochondrial gene expres...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9383 | biostudies-arrayexpress
TranscriptomicsExpression and SNP data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
This SuperSeries is composed of the following subset Series: GSE28365: Expression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative GSE28366: SNP data from genomic DNA from a subject, fibroblasts, iPSCs and neurons w...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-28367 | biostudies-arrayexpress
GenomicsSynapse related gene expression is downregulated in SPG7 patient induced pluripotent stem cell derived cortical neurons
Synapse related gene expression is downregulated in SPG7 patient induced pluripotent stem cell derived cortical neurons
PRJNA975577 | ENA
UnknownOligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons.
Not available
S-EPMC10444570 | biostudies-literature
TranscriptomicsSNP data from human fibroblasts and induced Pluripotent Stem cells.
We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-69287 | biostudies-arrayexpress
TranscriptomicsExtracellular vesicles isolated from human induced pluripotent stem cell-derived neurons contain a transcriptional network
Healthy brain function is mediated by several complementary signalling pathways, many of which are driven by extracellular vesicles (EVs). EVs are heterogeneous in both size and cargo and are constitutively released from cells into the extracellular milieu. They are subsequently trafficked to recipi...
ORGANISM(S): Homo sapiens 
2020-08-20 | E-MTAB-8254 | biostudies-arrayexpress
TranscriptomicsGene expresssion in human iPSC-derived neurons from normal and SPG3A donors
We performed RNA-seq experiments on two samples (cortical neurons and spinal motor neurons) from normal induced pluripotent stem cells (iPSCs), and another two samples (cortical neurons and spinal motor neurons) derived from SPG3A (an early onset form of hereditary spastic paraplegia) iPSCs. This in...
ORGANISM(S): Homo sapiens 
2019-03-25 | E-MTAB-7770 | biostudies-arrayexpress
TranscriptomicsTranscriptome data from induced Pluripotent Stem cells
We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-69288 | biostudies-arrayexpress
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