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MetabolomicsFecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus
The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patien...
2020-01-30 | MTBLS916 | MetaboLights
MetabolomicsLocal and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy
Cerebral ischemia and aging induce local and systemic effects, and impact severity of stroke outcome. We performed comprehensive metabolic profiling to detect metabolites in brain, plasma, and liver as a function of aging and ischemia/reperfusion (IR). Ischemic stroke was induced by middle cerebral ...
2019-02-01 | MTBLS516 | MetaboLights
MetabolomicsMulti-omics reveals taurine-mediated rumen microbial remodeling mitigates high-starch-diet-induced systemic inflammation and oxidative stress in fattening cattle

Background: With the pursuit of rapid intramuscular fat deposition in beef cattle, basal diets have increasingly shifted toward grain-based, energy-dense formulations. However, high-starch dietary regimens may induce host metabolic dysregulation, which is closely linked to both ruminal microbial ...

2025-09-25 | MTBLS13041 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
TranscriptomicsTranscriptional response of Arabidopsis thaliana in systemic acquired resistance: critical roles for pipecolic acid and salicylic acid
We investigated the relationships of the two immune-regulatory plant metabolites salicylic acid (SA) and pipecolic acid (Pip) in the establishment of plant systemic acquired resistance (SAR) in Arabidopsis thaliana induced by the bacterial pathogen Pseudomonas syringae. To characterize the transcrip...
ORGANISM(S): Arabidopsis thaliana 
2015-12-27 | E-MTAB-4151 | biostudies-arrayexpress
TranscriptomicsBarley Systemic Immunity: Dataset Local and Systemic
Leaf-to-leaf, systemic immune signaling known as systemic acquired resistance (SAR) is poorly understood in monocotyledonous plants. Here, we characterize systemic immunity in barley (Hordeum vulgare) triggered after primary leaf infection with either Pseudomonas syringae pathovar japonica (Psj) or ...
ORGANISM(S): Hordeum vulgare 
2014-11-24 | E-MTAB-3063 | biostudies-arrayexpress
TranscriptomicsBarley Systemic Immunity: Dataset Induced challenged
Leaf-to-leaf, systemic immune signaling known as systemic acquired resistance (SAR) is poorly understood in monocotyledonous plants. Here, we characterize systemic immunity in barley (Hordeum vulgare) triggered after primary leaf infection with either Pseudomonas syringae pathovar japonica (Psj) or ...
ORGANISM(S): Hordeum vulgare 
2014-11-24 | E-MTAB-3056 | biostudies-arrayexpress
MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsExploring Pinus nigra's induced defense arsenal against Diplodia sapinea through genes and metabolic pathway analysis

Two years-old Pinus nigra saplings from two different provenances (Austria and Corsica) were infected with Diplodia sapinea. Needles from the terminal shoot (distant tissue where systemic induced response might take place) were sampled always in the morning. Samples were taken 3, 8 and 21 days af...

2026-01-12 | MTBLS13184 | MetaboLights
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