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ProteomicsInfluenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans
Proteomic analysis of serum IgG antibody repertoire against influenza vaccine H1 (H1N1 A/California/7/2009) and H3 (H3N2 A/Texas/50/2012) in young, middle-aged, and elderly donors vaccinated with Fluzone 2013-14/14-15. Dataset consists of peak-response (days 21-28 post-vaccination) serum IgG samples...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086108 | MassIVE
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections.
The objective of this study is to: 1) Characterize the immune responsiveness to administration of non-live vaccines in three cohorts of healthy adult subjects through the analysis of blood leukocytes transcriptional profiles. 2) Validate whole blood transcriptional profiles generated from standard 3...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-30101 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections II
The objective of this study is to: 1) Characterize the immune responsiveness to administration of non-live vaccines in three cohorts of healthy adult subjects through the analysis of blood leukocytes transcriptional profiles. 2) Validate whole blood transcriptional profiles generated from standard 3...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-48762 | biostudies-arrayexpress
TranscriptomicsTrivalent Inactivated Influenza Vaccine (TIV) and Live Attenuated Influenza Vaccine (LAIV) Induce Different B cell and Transcriptional Responses in Children
LAIV and TIV are effective for prevention of influenza infection in children, but the mechanisms associated with protection are still not well defined. We analyzed the differences in B cell responses and transcriptional profiles. Compared to baseline, LAIV elicited a significant increase in naM-CM-/...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52005 | biostudies-arrayexpress
ProteomicsImmunosignatures can predict vaccine efficacy
Mice were immunized with either formalin fixed Influenza A/PR/8/34 (Killed PR8), the 2006-2007 seasonal influenza vaccine, the 2007-2008 seasonal influenza vaccine, a sublethal infection (live PR8) or mock immunized (PBS). Array data was used to distinguish the immunogens from each other and predic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-51623 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 1
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59635 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 2
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59654 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections I
The objective of this study is to: 1) Characterize the cellular origin of transciptional signatures observed on day 1 after vaccination with 2009/10 seasonal influenza and pneumococcal vaccine discovered by transcriptional profiling of whole blood samples in data set “WholeBlood_SysVax”. 2) Discover...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-30059 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus
The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG...
ORGANISM(S): Mustela putorius furo 
2011-02-11 | E-GEOD-27248 | biostudies-arrayexpress
GenomicsInduction of trained immunity by influenza vaccine: impact on COVID-19
Cross-protective effects of certain vaccines against heterologous infections have been reported, and long-term boosting of innate immunity (also termed trained immunity) has been proposed as the underlying mechanism. Several epidemiological studies suggested cross-protection between influenza vaccin...
EGAS00001005446 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
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