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MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
TranscriptomicsThe human mitochondrial transcriptome
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs and rRNAs. Here we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell li...
ORGANISM(S): Homo sapiens 
2011-07-20 | E-GEOD-30772 | biostudies-arrayexpress
TranscriptomicsATFS-1 mediates a protective transcription program during mitochondrial stress
ATFS-1 has been shown to regulate transcription of mitochondrial chaperone genes such as mtHsp70/hsp-6 and hsp-60 in response to mitocondrial stress. To identify the entire ATFS-1-mediated response, we compared the transcript profiles from wild-type and atfs-1(tm4525) worms raised in the absence and...
ORGANISM(S): Caenorhabditis elegans 
2012-07-11 | E-GEOD-38196 | biostudies-arrayexpress
TranscriptomicsArabidopsis transcription factor ANAC017 is a necessary and central control point for normal transcriptome changes in response to reactive oxygen signals, such as H2O2, and specific mitochondrial retrograde stress signals
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde communication pathways within the cell. rao2 mutants contain a mutation in the NAC family transcription factor ANAC017 and cannot induce stress r...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-41136 | biostudies-arrayexpress
ProteomicsMetabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Cancer cells depend on mitochondria to sustain their increased metabolic needs therefore, mitochondria constitute an interesting target for cancer treatment. We recently developed novel small-molecule inhibitors of mitochondrial transcription (IMTs) that selectively target mitochondrial gene express...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026481 | Pride
Mtdna Cancer Crispr-cas9 genetic screen Inhibitor of mitochondrial transcription Chemoresistance 
TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
GenomicsTFAM ChIP-seq in HeLa cells
ChIP-seq data characterizing the occupancy of TFAM over the mitochondrial and nuclear genomes in HeLa cells. Characterization of mitochondrial and nuclear genome-wide TFAM binding in HeLa cells
ORGANISM(S): Homo sapiens 
2013-09-21 | E-GEOD-48176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse TSC2-/- embryonic fibroblasts: vehicle-treated, rapamycin-treated, gfp-infected, and pgc-1alpha-infected samples reveals the mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex
Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxid...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5332 | biostudies-arrayexpress
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