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MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
MetabolomicsHigher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance
Not available
ORGANISM(S): Mus musculus 
ST001635 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Not available
ORGANISM(S): Homo sapiens 
ST001730 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001732 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001731 | MetabolomicsWorkbench
ProteomicsLabel Free Quantification Mass Spectrometry Identifies Protein Markers of Chemoresistance in Serous Ovarian Cancer
Ovarian cancer is still the most lethal gynecological cancer, despite advances in patients’ strati-fication and treatment. Only about 80% of patients respond to the first line of treatment and many suffer a relapse with a treatment resistant disease. Here, we have identified three potential markers ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033785 | Pride
Chemoresistance Mass-spectrometry Ovarian cancer 
ProteomicsmTORC2-driven chromatin cGAS mediates chemoresistance in colorectal cancer
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited. However, the mechanisms underlying cGAS recruitment to chromatin and the functions of chromatin-bound cGAS (ccGAS) re...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053068 | Pride
Mtorc2 Chromatin cgas Phosphorylation Kga Chemoresistance 
ProteomicsNucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Emerging evidence indicates that metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. In this study, utilizing a metabolic CRISPR-Cas9 knockout library screen, we ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-15 | PXD055376 | Pride
Nuclear gclm  moonlighting function  nkrf  phosphorylation  chemoresistance lc-ms/ms 
ProteomicsProteomic signature of neuroblastoma cells UKF-NB-4 reveals key role of lysosomal sequestration and the proteasome complex in acquiring chemoresistance to cisplatin
Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analysed established ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD012132 | Pride
Chemoresistance V-atpases Lysosomes Neuroblastoma Cisplatin Proteomics 
GenomicsFOXA1 promotes SCLC chemoresistance [ChIP-Seq]
FOXA1 promotes SCLC chemoresistance [ChIP-Seq]
PRJNA1379438 | ENA
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