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UnknownStructural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
Not available
S-EPMC4929687 | biostudies-literature
UnknownO-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma.
Not available
S-EPMC11982200 | biostudies-literature
UnknownStructural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Not available
S-EPMC3356676 | biostudies-literature
ProteomicsmTORC2-driven chromatin cGAS mediates chemoresistance in colorectal cancer
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited. However, the mechanisms underlying cGAS recruitment to chromatin and the functions of chromatin-bound cGAS (ccGAS) re...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053068 | Pride
Mtorc2 Chromatin cgas Phosphorylation Kga Chemoresistance 
TranscriptomicsThe Gac regulon in Pseudomonas chlororaphis 30-84
The GacS/GacA two component regulatory system globally activates the production of secondary metabolites including phenazines in Pseudomonas chlororaphis 30-84. To better understand the regulatory role of the Gac system, we conducted RNA-seq analyses to determine the regulon of the response regulato...
ORGANISM(S): Pseudomonas chlororaphis subsp. aureofaciens 30-84 
2014-12-11 | E-GEOD-43083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human THP-1 cells wild type vs overexpressing GAM or siRNAs directed against GAM (siGAM) challenged by LPS
24 hours following transfection with either a control mix, a construct overexpressing GAM or siRNAs directed against GAM (siGAM), THP-1 cells were challenged with LPS 100 ng/ml. RNAs were analyzed after 6 hours of LPS challenge
ORGANISM(S): Homo sapiens 
2010-06-09 | E-TABM-868 | biostudies-arrayexpress
TranscriptomicsEffect of intracellular acidification on senescence-related transcriptomic changes
Several remodeling of intracellular environments has been identified in senescent cells, including enlargement of cell / nuclear size and intracellular acidification. Although these alterations of intracellular environments were reported to be involved in unique characteristics of senescent cells, t...
ORGANISM(S): Mus musculus 
2024-04-28 | GSE252672 | GEO
UnknownCombinatorial metabolic engineering of industrial Gluconobacter oxydans DSM2343 for boosting 5-keto-D-gluconic acid accumulation.
Not available
S-EPMC4869267 | biostudies-literature
MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
UnknownCFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.
Not available
S-EPMC4878610 | biostudies-literature
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