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MetabolomicsSARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Not available
ORGANISM(S): Homo sapiens 
ST001709 | MetabolomicsWorkbench
ProteomicsPhosphoproteomic Analysis Defines BABAM1 as mTORC2 Downstream Effector Promoting DNA Damage Response in Glioblastoma Cells
Glioblastoma (GBM) is a devastating primary brain cancer with a poor prognosis. GBM is associated with an abnormal mechanistic target of rapamycin (mTOR) signaling pathway, consisting of two distinct kinase complexes: mTORC1 and mTORC2. The complexes play critical roles in cell proliferation, surviv...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD033325 | Pride
Phosphoproteomics Mtorc2 Glioblastoma Babam1 Dna damage 
ProteomicsA Long-Range Recruitment Mechanism for mTORC2 Phosphorylation of Akt
Study of the phosphorylation of human Akt1 (Akt) by mTOR complex 2 (mTORC2) in vitro. Akt was prepared by semi-synthesis, resulting in a non-phosphorylated C-tail, allowing unbiased study of the sites phosphorylated by mTORC2. Because enzymologic data showed that the canonical hydrophobic motif resi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD048719 | Pride
Akt Agc kinase Mtorc2 Mtor Phosphorylation Hydrophobic motif 
ModelsDallePezze2012 - TSC-independent mTORC2 regulation
DallePezze2012 - TSC-independent mTORC2 regulation This model is described in the article: A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, B...
2024-09-02 | BIOMD0000000581 | BioModels
ProteomicsmTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
The mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here we elaborate that mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 resulted in impai...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035256 | Pride
Glioblastoma Ap-ms Mtorc2 interactome Cell migration Gelsolin 
TranscriptomicsExpression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)
Recent work using mouse models has revealed that mTORC2, which unlike mTORC1 is not acutely sensitive to rapamycin, plays a key role in the regulation of organismal physiology. The substrates and pathways regulated by mTORC2 are at present relatively unknown Using a mouse model with a targeted delet...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-46515 | biostudies-arrayexpress
ProteomicsmTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter...
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD006461 | Pride
Mtorc2 Xct 
ProteomicsQuantitative analysis of the mouse brain phosphoproteome in mTORC2 KO mutants
Here we are using unbiased phosphoproteomics analyses to try to identify selective targets of mTORC2 in mouse brain.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-20 | PXD045878 | Pride
Mouse Tmt Mtorc2 Phosphorylation 
GenomicsEpigenome analysis of control and mTORC2-suppressed glioblastoma cells
Epigenome analysis of control and mTORC2-suppressed glioblastoma cells
PRJNA985551 | ENA
ProteomicsRictor/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition
Nearly 50% of cutaneous melanomas carry activating mutations on the BRAF oncogene, and the combination of BRAF- and MEK-inhibitors (BRAF/MEKi) is frequently used for their clinical management. One major drawback of BRAF/MEKi targeted therapy is the rapid development of therapeutic resistance, which ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045346 | Pride
Brafv600e Mtorc2 Braf Rictor Melanoma 
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