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ProteomicsmTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter...
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD006461 | Pride
Mtorc2 Xct 
TranscriptomicsGenomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), a rapidly progressing malignancy mostly arising in HIV-infected patients. Even under conventional chemotherapy, PEL continues to portend nearly 100% mortality within several months, which ur...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65418 | biostudies-arrayexpress
GenomicsInhibition of xCT Suppresses Melanoma progress
Inhibition of xCT Suppresses Melanoma progress
PRJNA701281 | ENA
ProteomicsTumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma
Objectives: Epileptogenesis in human glioma is linked to increased glutamate signaling that is primarily facilitated by xCT, suggesting it as a pharmacological target for anti-seizure medication (ASM). Here, we investigated the expression of xCT in glioma-associated epilepsy and investigated the imp...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD062733 | Pride
Human glioma Xct 
GenomicsMicrovirga tunisiensis strain:XCT-34
Microvirga tunisiensis strain:XCT-34 Genome sequencing
PRJNA643673 | ENA
TranscriptomicsInhibition of xCT Suppresses Melanoma progress
Tumor cells increase glutamate release through the cystine/glutamate transporter xCT to balance oxidative homeostasis in tumor cells and promote tumor progression. Here, we demonstrated that although inhibition of xCT either by pharmacological inhibitor (sulfasalazine, SAS), approved by FDA for infl...
ORGANISM(S): Mus musculus 
2021-02-11 | GSE166566 | GEO
GenomicsThe Deubiquitylase USP52 Regulates Cell Proliferation and Ferroptosis through Stabilizing SLC7A11/xCT in Bladder Cancer
The Deubiquitylase USP52 Regulates Cell Proliferation and Ferroptosis through Stabilizing SLC7A11/xCT in Bladder Cancer
PRJNA1095871 | ENA
TranscriptomicsXCT is a novel regulator of chromatin functionally conserved across eukaryotes
XCT was originally identified due to the short circadian period observed in plants mutant for this gene. Proteins with homology to XCT are found across eukaryotes, but their molecular function is unknown. We have recently demonstrated that in Schizosaccharomyces pombe, the XCT ortholog Xap5 is a chr...
ORGANISM(S): Arabidopsis thaliana 
2019-05-01 | GSE67813 | GEO
TranscriptomicsRole of the glial glutamate exchanger xCT in ventral hippocampus in resilience to stress
We demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and established a previously unknown role for the glial marker xCT in the homeostatic regulation of the ventral dentate gyrus (vDG) in stress resilience and antidepressant responses. We pr...
ORGANISM(S): Mus musculus 
2017-10-11 | GSE103435 | GEO
TranscriptomicsThe Deubiquitylase USP52 Regulates Cell Proliferation and Ferroptosis through Stabilizing SLC7A11/xCT in Bladder Cancer
Ferroptosis, a recently coined non-apoptotic form of cell death, is triggered by lethal accumulation of iron-dependent lipid peroxidation. SLC7A11/xCT, acts as a central hub in ferroptosis, is closely related to the development of multiple human diseases. However, the specific functions and potentia...
ORGANISM(S): Homo sapiens 
2024-12-09 | GSE263111 | GEO
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