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TranscriptomicsDeletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure
The mammalian target of rapamycin complex 2 (mTORC2) contains the essential protein RICTOR and is activated by growth factors. mTORC2 in adipose tissue contributes to regulating glucose and lipid metabolism. In the perivascular adipose tissue (PVAT) mTORC2 ensures normal vascular reactivity by contr...
ORGANISM(S): Mus musculus 
2015-07-05 | E-GEOD-67077 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)
Recent work using mouse models has revealed that mTORC2, which unlike mTORC1 is not acutely sensitive to rapamycin, plays a key role in the regulation of organismal physiology. The substrates and pathways regulated by mTORC2 are at present relatively unknown Using a mouse model with a targeted delet...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-46515 | biostudies-arrayexpress
TranscriptomicsCritical roles of Rictor/Sin1complexes in IFN-dependent Stat activation and generation of antiproliferative responses
We provide evidence that IFN-induced Stat-activation is defective in cells with targeted disruption of the Rictor gene, whose protein product is a key element of mTOR complex 2 (mTORC2). Our studies show that transient or stable knockdown of Rictor leads to decreased expression of several IFN-indu...
ORGANISM(S): Mus musculus 
2014-01-28 | E-GEOD-47896 | biostudies-arrayexpress
GenomicsRNA sequencing of Rictor-deficient epidermis
RNA sequencing of Rictor-deficient epidermis
PRJNA551008 | ENA
ProteomicsRictor/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition
Nearly 50% of cutaneous melanomas carry activating mutations on the BRAF oncogene, and the combination of BRAF- and MEK-inhibitors (BRAF/MEKi) is frequently used for their clinical management. One major drawback of BRAF/MEKi targeted therapy is the rapid development of therapeutic resistance, which ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045346 | Pride
Brafv600e Mtorc2 Braf Rictor Melanoma 
ProteomicsRICTOR/mTORC2 downregulation in BRAF V600E melanoma cells promotes resistance to BRAF/MEK inhibition
Background Main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF- mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to define in this context the specific role of mTORC2, a signaling complex defined by the pr...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD050614 | Pride
Targeted therapy Rictor Braf v600e melanoma Mitochondrial metabolism Drug resistance Nampt Mtorc2 
GenomicsEffect of myeloid specific rictor knockout on B16-F10 tumors grown in mice
Effect of myeloid specific rictor knockout on B16-F10 tumors grown in mice
PRJNA1282685 | ENA
GenomicsGene expression data from LCMV-specific Rictor-/- and WT follicular T helper cells
Gene expression data from LCMV-specific Rictor-/- and WT follicular T helper cells
PRJNA437310 | ENA
TranscriptomicsRictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia
Little is known about the roles of Rictor/mTORC2 in the leukemogenesis of AML. Here, we demonstrated that Rictor is essential for the maintenance of MLL-driven leukemia by preventing LSCs from exhaustion. Rictor depletion led to a reactive activation of mTORC1 signaling by facilitating the assembly ...
ORGANISM(S): Mus musculus 
2016-07-19 | E-GEOD-84505 | biostudies-arrayexpress
GenomicsWhole transcriptomes analyses of control and Rictor knockout intestinal epithelial cells
Whole transcriptomes analyses of control and Rictor knockout intestinal epithelial cells
PRJNA1017852 | ENA
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