The Gac regulon in Pseudomonas chlororaphis 30-84

ABSTRACT: The GacS/GacA two component regulatory system globally activates the production of secondary metabolites including phenazines in Pseudomonas chlororaphis 30-84. To better understand the regulatory role of the Gac system, we conducted RNA-seq analyses to determine the regulon of the response regulator GacA. Transcriptome analyses identified over 700 genes differentially regulated by GacA. Consistent with our previous findings, phenazine biosynthetic genes were significantly down-regulated in a gacA mutant. The expression levels of phenazine regulatory genes such as phzI, phzR, iopA, iopB, rpoS and pip were also decreased. Moreover, the expression of three none-coding RNAs (ncRNAs) including rsmX, rsmY and rsmZ was significantly decreased by gacA mutation consistent with the presence of GacA

ORGANISM(S): Pseudomonas chlororaphis subsp. aureofaciens 30-84

SUBMITTER: Dongping Wang 

PROVIDER: E-GEOD-43083 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress