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UnknowniRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.
Not available
S-EPMC8997904 | biostudies-literature
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 5A, S5A-B]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060331 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 4D, S4D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060334 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 3C, 5A, S3F-G, S6A]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060309 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 7F, S7E-F, S7H-I]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060308 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 7D, S7G]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060301 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 5B, S5C-E]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060206 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 5C, S5F]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060207 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 1F, 2A-C, 3A-C, 6A, S1F, S2A, S3A-D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060355 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
ProteomicsRNF10 and RIOK3 Facilitate 40S Ribosomal Subunit Degradation upon 60S Biogenesis Disruption or Amino Acid Starvation [Fig. 6B-D]
Ribosome-associated quality control (RQC) pathways target ribosomes whose progression becomes impaired during various phases of the translation cycle. Ribosome ubiquitylation is a key RQC licensing step. Previous studies identified an initiation specific RQC branch (iRQC) that is activated when tran...
ORGANISM(S): Homo sapiens (Human) 
2025-02-07 | PXD060208 | Pride
Riok3 Ribosome ubiquitylation Initiation ribosome-associated quality control (irqc) Amino acid starvation Rnf10 Ribosome biogenesis 
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