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TranscriptomicsFeedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9200 | biostudies-arrayexpress
TranscriptomicsExpression profile of BCR-ABL1-transformed, Cdk4 R24C, Cdk6 R31C cell lines
Cdk4 and Cdk6 are two related kinases that bind D-type cyclins and regulate cell cycle progression. Due to their relevance in cancer, Cdk4/6 inhibitors are currently in advanced clinical trials in multiple tumor types. Cdk4/6 are inhibited by INK4 proteins that exert tumor suppressing functions. To ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-59024 | biostudies-arrayexpress
GenomicsUnderstanding BRCA1 function in INK4-RB deficient tumors
Understanding BRCA1 function in INK4-RB deficient tumors
PRJNA655906 | ENA
GenomicsChromatin conformation dynamics are essential to control the transcription of INK4/ARF locus
Chromatin conformation dynamics are essential to control the transcription of INK4/ARF locus
PRJNA490758 | ENA
GenomicsChromatin Conformation Dynamics are essential to Control the Transcription of INK4/ARF locus
Chromatin Conformation Dynamics are essential to Control the Transcription of INK4/ARF locus
PRJNA488260 | ENA
TranscriptomicsUnderstanding BRCA1 function in INK4-RB deficient tumors
Most BRCA1-deficient BLBCs carry a dysfunctional INK4-RB pathway. Thus, we have created genetically engineered mice with Brca1 loss and deletion of p16INK4A, or separately p18INK4C, to model the deficient INK4-RB signaling in human BLBC. By using these mutant mice and human BRCA1 deficient and profi...
ORGANISM(S): Mus musculus 
2021-01-27 | GSE155239 | GEO
TranscriptomicsTranscription profiling by array of human glioblastoma frozen tumors and cell lines
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9171 | biostudies-arrayexpress
UnknownStructural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
Not available
S-EPMC317144 | biostudies-literature
UnknownThe Ink4/Arf locus is a barrier for iPS cell reprogramming.
Not available
S-EPMC3578184 | biostudies-literature
TranscriptomicsChromatin conformation dynamics are essential to control the transcription of INK4/ARF locus
The INK4/ARF (CDKN2A/B) locus has been identified as a hotspot for susceptibility to genetic changes associated with a vast variety of cancers and aging related diseases including coronary artery disease and type II diabetes. Using chromatin Capture-C technologies, we discovered a distal enhancer up...
ORGANISM(S): Homo sapiens 
2024-08-01 | GSE119947 | GEO
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