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MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
MetabolomicsPhosphoethanolamine Cytidylyltransferase 2 Integrates DAG Metabolism and TBK1 Activation to Regulate Antiviral Innate Immunity

Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular homeostasis. However, its specific role in antiviral innate immunity remains poorly understood. Here, we demonstrate that inhibition of phosphoethanolamine cytidylyltransferase 2 (PCYT2), a key enzyme in...

2026-05-07 | MTBLS14085 | MetaboLights
MetabolomicsMulti-omics of OsGF14b-mediated innate immunity against panicle blast in rice
Not available
ORGANISM(S): Oryza sativa Japonica Group 
ST001330 | MetabolomicsWorkbench
MetabolomicsMulti-omics of OsGF14b-mediated innate immunity against panicle blast in rice (part-II)
Not available
ORGANISM(S): Oryza sativa Japonica Group 
ST001331 | MetabolomicsWorkbench
ProteomicsTranscriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
ORGANISM(S): Olavius Algarvensis (ncbitaxon:188229) 
2016-02-12 | MSV000079512 | MassIVE
ModelsPhan2017 - innate immune in oncolytic virotherapy
The paper describes a model on the key components for tumor–immune dynamics in multiple myeloma. Created by COPASI 4.25 (Build 207) This model is described in the article: The Role of the Innate Immune System in Oncolytic Virotherapy Tuan Anh Phan and Jianjun Paul Tian Computational and Mathema...
2024-09-02 | BIOMD0000000748 | BioModels
Immuno-oncology 
Transcriptomicshyperlipidemia impaired innate response
To explore the effect of hyperlipidemia on macrophages' innate immune response to Porphyromonas gingivalis invasion 12 samples, 3 replicates in 4 groups, with cells from hyperlipidemic ApoE deficient mice and nonhyperlipidemic C57BL/6 mice stimulate with or without P.gingivalis(Pg)
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-42061 | biostudies-arrayexpress
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