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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
MetabolomicsPhosphoethanolamine Cytidylyltransferase 2 Integrates DAG Metabolism and TBK1 Activation to Regulate Antiviral Innate Immunity

Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular homeostasis. However, its specific role in antiviral innate immunity remains poorly understood. Here, we demonstrate that inhibition of phosphoethanolamine cytidylyltransferase 2 (PCYT2), a key enzyme in...

2026-05-07 | MTBLS14085 | MetaboLights
MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
ProteomicsTranscriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
ORGANISM(S): Olavius Algarvensis (ncbitaxon:188229) 
2016-02-12 | MSV000079512 | MassIVE
TranscriptomicsPreadaptation of Yersinia pestis to resist mammalian innate immunity during transit through the flea vector
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37°C induces many known virulence factors...
ORGANISM(S): Yersinia pestis 
2010-04-06 | E-GEOD-16493 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of LPS-stimulated RAW264.7 macrophages overexpressing Tbc1d23 novel innate immune gene
We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using mice with an engineered knockout mutation in Tbc1d23 and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a ...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-30840 | biostudies-arrayexpress
TranscriptomicsVirus-misplaced host protein activates innate immunity
Discrimination between self vs. non-self and adequate response to infection and tissue damage are fundamental functions of the immune system. The rapid and global spread of known and emerging viruses is a testament that the timely detection of viral pathogens that reproduce within host cells, presen...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-36078 | biostudies-arrayexpress
TranscriptomicsHuman keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-30355 | biostudies-arrayexpress
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