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GenomicsGenome wide mapping of AR and its associated factors in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and its associated factors such as coregulators or collaborating factors.In addition, by siRNA mediated knockdown of s...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-58428 | biostudies-arrayexpress
TranscriptomicsLNCaP cells: shRNA library with bicalutamide
Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth Vehicle vs. bicalutamide treated LNCaP cells infected with lentiviral shRNA library. Biological replicates: 2 vehicle treatments, 2 bicalutamide treatments.
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-60382 | biostudies-arrayexpress
TranscriptomicsThe role of AR-associated factors in androgen signaling
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in pr...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-58309 | biostudies-arrayexpress
GenomicsGenome wide analysis of AR binding sites and histone modifications in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sit...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-62492 | biostudies-arrayexpress
GenomicsRegulation of androgen receptor signaling by Oct1 recruitment in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed ChIP sequence analysis in AR-positive prostate cancer cell lines, LNCaP and VCaP. In addition, we also examined the effect of PI pol...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-77770 | biostudies-arrayexpress
TranscriptomicsTime course of androgen-regulated transcripts in LNCaP cells
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed RNA sequence analysis in AR positive prostate cancer cell line, LNCaP. RNA sequence analysis of androgen-regulated transcripts in pr...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-70150 | biostudies-arrayexpress
TranscriptomicsInvestigation of androgen-regulated lncRNAs in prostate cancer cells
Prostate cancer is the most common cancer in men and androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed directional RNA sequence analysis in AR positive prostate cancer cell line, LNCaP and VCaP. Using Noncode and GE...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-82223 | biostudies-arrayexpress
GenomicsGenome wide analysis of androgen-receptor binding sites and epigenetic condition in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. To investigate the AR signaling, we performed ChIP sequence analysis in AR positive prostate cancer cell line, LNCaP. In addition, we used hormone-refractory prostate cancer mode...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-66037 | biostudies-arrayexpress
TranscriptomicsGeneration of Cloned Mice from Adult Neurons by Direct Nuclear Transfer
Whereas cloning mammals by direct somatic cell nuclear transfer has been successful using a wide range of donor cell types, neurons from adult brain remain M-bM-^@M-^\unclonableM-bM-^@M-^] for unknown reasons. Here we examined whether neurons from adult mice could be cloned, using a combination of t...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-65497 | biostudies-arrayexpress
TranscriptomicsExpression Data from DMSO or SRPIN803 treated ARPE-19 cells
We used microarrays to evaluate the effect of SRPIN803 on gene expression in ARPE-19 cells. ARPE-19 cells were treated with SRPIN803 (10 uM) or the negative control (0.1% DMSO) for 4 hours for Total RNA isolation and hybridization on Microarray.
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-62947 | biostudies-arrayexpress
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