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MetabolomicsComprehensive metabolomics reveals defence-driven metabolic reprogramming via withanoside biosynthesis under insect herbivory in Withania somnifera

Plants exhibit dynamic physiological and biochemical responses to herbivory that often involve extensive metabolic reprogramming. Withania somnifera (Ashwagandha), a globally important medicinal plant, is susceptible to herbivory by the pest Henosepilachna vigintioctopunctata, resulting in signif...

2026-02-17 | MTBLS13904 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
TranscriptomicsTranscription profiling of C. elegans after infection with Microbacterium nematophilum
Genomic response of C. elegans after infection with Microbacterium nematophilum.

The interaction between the nematode Caenorhabditis elegans and a Gram-positive bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune response in nematodes. This pathogen adheres ...
ORGANISM(S): Caenorhabditis elegans 
2005-01-01 | E-MEXP-696 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum during infection on different insects
We used RNA-Seq to compare transcriptional responses of M. anisopliae and M. acridum to infection of the optically clear hind wings of adult locusts and cockroaches. It was calculated that >82% of predicted M. anisopliae genes and >88% of predicted M. acridum genes were expressed during pre-penetrat...
ORGANISM(S): Metarhizium acridum 
2011-01-31 | E-GEOD-24938 | biostudies-arrayexpress
TranscriptomicsGenome scale analysis of host-virus mRNA differential expression in Helicoverpa zea insect cells infected by H. armigera baculovirus from early till late infection
A custom microarray, based on deep transcriptome sequencing ((GEO accession number: GSE34418), was used to simultaneously investigate expression of over 24,000 Helicoverpa zea insect transcripts and 134 H. armigera nucleopolyhedrovirus (HearNPV) genes throughout the infection process at 0, 12, 24 an...
ORGANISM(S): Helicoverpa zea 
2013-03-01 | E-GEOD-44184 | biostudies-arrayexpress
MetabolomicsApolipophorin-III modulates antiviral defense in Bombyx mori: an integrated transcriptomic and lipidomic analysis of its inhibitory role against BmNPV infection.

The silkworm (Bombyx mori) is an economically important insect and a lepidopteran model organism. Controlling viral infections is crucial for the sustainable development of sericulture. Bombyx mori nucleopolyhedrovirus (BmNPV) infection can cause large-scale mortality in silkworm populations. Ins...

2025-12-03 | MTBLS13447 | MetaboLights
TranscriptomicsImpact of Nosema apis and Nosema ceranae co-infection on worker fat body gene expression
Newly emerged adult workers (24 hours old) were infected with 25,000 Nosema apis spores and 25,000 Nosema ceranae spores in sucrose solution. Controls were fed sucrose. Workers were maintained in cages in an incubator and collected at 14 days post-infection. Fat bodies (eviscerated abdomens) were di...
ORGANISM(S): Apis mellifera 
2014-05-01 | E-MEXP-3889 | biostudies-arrayexpress
TranscriptomicsImpact of Nosema apis infection on worker honey bee fat body gene expression
Newly emerged adult workers (24 hours old) were infected with 50,000 Nosema apis spores in sucrose solution. Controls were fed sucrose. Workers were maintained in cages in an incubator and collected at 2 and 7 days post-infection. Fat body tissue was dissected (eviscerated abdomen) and whole geno...
ORGANISM(S): Apis mellifera 
2014-05-03 | E-MEXP-3892 | biostudies-arrayexpress
GenomicsMicroRNAs regulate differential innate immune response to uropathogenic and commensal-like Escherichia coli infection in the surrogate insect model Galleria mellonella
MicroRNAs regulate differential innate immune response to uropathogenic and commensal-like Escherichia coli infection in the surrogate insect model Galleria mellonella
PRJNA510393 | ENA
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