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ProteomicsGenetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, while beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabete...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-24 | PXD000859 | Pride
B10 mice Inshel Diabetes Nod mice 
TranscriptomicsThymic deletion in B10 430B
Microarray analysis of thymic deletion in the B10 mouse strain The gene expression patterns of thymocytes at the pre-selection stage and undergoing positive selection or negative selection were compared in the C57BL/10-H2k (B10k) strain. In order to sort thymocytes homogenously undergoing positive s...
ORGANISM(S): Mus musculus 
2008-11-01 | GSE9700 | GEO
TranscriptomicsTranscription profiling of mouse thymic deletion in B10 430B strains
Microarray analysis of thymic deletion in the B10 mouse strain; The gene expression patterns of thymocytes at the pre-selection stage and undergoing positive selection or negative selection were compared in the C57BL/10-H2k (B10k) strain. In order to sort thymocytes homogenously undergoing positive...
ORGANISM(S): Mus musculus 
2008-11-13 | E-GEOD-9700 | biostudies-arrayexpress
TranscriptomicsComparative assessment of the transcriptome of pancreatic islets from Non-Obese Diabetic mice in the absence of immune infiltrate
The transcriptome of pancreatic islets from four mouse strains was compared - NODk.RagKO, B10k.RagKO, NODk.RagKO.insHEL and B10k.RagKO.insHEL. This comparison allows the assessment of altered transcriptome due to two factors - genetic background of NOD vs B10 strain, and the effect of the insHEL tra...
ORGANISM(S): Mus musculus 
2016-02-23 | GSE56507 | GEO
TranscriptomicsComparative assessment of the transcriptome of pancreatic islets from Non-Obese Diabetic mice in the absence of immune infiltrate
The transcriptome of pancreatic islets from four mouse strains was compared - NODk.RagKO, B10k.RagKO, NODk.RagKO.insHEL and B10k.RagKO.insHEL. This comparison allows the assessment of altered transcriptome due to two factors - genetic background of NOD vs B10 strain, and the effect of the insHEL tra...
ORGANISM(S): Mus musculus 
2016-02-23 | E-GEOD-56507 | biostudies-arrayexpress
GenomicsMus musculus
Thymic deletion in B10 430B
PRJNA103603 | ENA
GenomicsMus musculus
Comparative assessment of the transcriptome of pancreatic islets from Non-Obese Diabetic mice in the absence of immune infiltrate
PRJNA243560 | ENA
TranscriptomicsTranscription profiling of mouse T cell populations undergoing negative or positive selection for an Aire-dependent organ specific antigen
Background. T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor (TCR) with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood, desp...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3997 | biostudies-arrayexpress
GenomicsMus musculus
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: analysis by mRNA profiling
PRJNA94273 | ENA
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