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ProteomicsInstaNovo-P T47D cell phosphoproteomics
Phosphorylation, a vital post-translational modification (PTM), plays a central role in cellular signaling and disease mechanisms. Mass spectrometry-based phosphoproteomics is widely used for system-wide characterization of phosphorylation events. However, traditional methods struggle with accurate ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD062859 | Pride
Breast cancer Growth factor Phosphoproteomics 
ProteomicsInstaNovo-P: A de novo peptide sequencing model for phosphoproteomics
Phosphorylation, a crucial post-translational modification (PTM), plays a central role in cellular signaling and disease mechanisms. Mass spectrometry-based phosphoproteomics is widely used for system-wide characterization of phosphorylation events. However, traditional methods struggle with accurat...
ORGANISM(S): Homo sapiens (Human) 
2026-05-20 | PXD074105 | Pride
Instanovo  de novo sequencing  phosphoproteomics  breast cancer  fgfr2 signaling 
ProteomicsInstaNovo enables diffusion-powered de novo peptide identification in large scale proteomics experiments
Bottom-up mass spectrometry-based proteomics is challenged by the task of identifying the peptide that generates a tandem mass spectrum. Traditional methods that rely on known peptide sequence databases are limited and may not be applicable in certain contexts. De novo peptide sequencing, which assi...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD044934 | Pride
Peptidomics Machine learning Protein sequencing Proteomics De novo sequencing 
ProteomicsInstaNovo-P: A de novo peptide sequencing model for phosphoproteomics
Phosphorylation, a vital post-translational modification (PTM), plays a central role in cellular signaling and disease mechanisms. Mass spectrometry-based phosphoproteomics is widely used for system-wide characterization of phosphorylation events. However, traditional methods struggle with accurate ...
ORGANISM(S): Homo Sapiens 
PXD063292 | panorama
UnknownA transformer-based semi-autoregressive framework for high-speed and accurate de novo peptide sequencing.
Not available
S-EPMC11825679 | biostudies-literature
UnknownModanovo: A Unified Model for Post-translational Modification-Aware De Novo Sequencing Using Experimental Spectra From In Vivo and Synthetic Peptides.
Not available
S-EPMC12860953 | biostudies-literature
ProteomicsGeneralizable direct protein sequencing with InstaNexus
Critical protein therapeutics, such as antibodies and nanobodies, are often not encoded in reference genomes, limiting their accurate characterization via standard proteomics. Current methods rely on indirect inference, fragmented outputs, and labor-intensive workflows, which hinder functional insig...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-02-23 | PXD066160 | Pride
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