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TranscriptomicsTranscription profiling of human neutrophils obtained after exposure endotoxin by bronchoscopic instillation reveals differential gene expression between air space and circulating neutrophils
Although the accumulation of neutrophils in the lungs and airways is common to many inflammatory lung diseases, including acute lung injury, the alterations that neutrophils undergo as they leave the peripheral circulation and migrate into the lungs have not been well characterized. Human volunteers...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2322 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs)
Gene expression profiling of the rat lung following intratracheal instillation with SWCNTs was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at ...
ORGANISM(S): Rattus norvegicus 
2013-09-07 | E-GEOD-50664 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat lung following intratracheal instillation with impurity-free single-wall carbon nanotubes
To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physi...
ORGANISM(S): Rattus norvegicus 
2014-09-17 | E-GEOD-61483 | biostudies-arrayexpress
GenomicsIntratracheal instillation of quaternary ammonium compounds in rats
Intratracheal instillation of quaternary ammonium compounds in rats
PRJNA1096695 | ENA
TranscriptomicsmRNA reponse to bleomycin instillation
Gene expression analysis of C57BL/6 mice challenged by intratracheal bleomycin instillation: mRNA expression profiles were established from lungs following a 14-days PBS or bleomycin administration.
ORGANISM(S): Mus musculus 
2013-02-01 | GSE34814 | GEO
TranscriptomicsChanges in cholesterol homeostasis and acute phase response following pulmonary exposure to multi-walled carbon nanotubes links carbon nanotube exposure to risk of cardiovascular disease
Adverse lung effects in rodents following pulmonary exposure to multi-walled carbon nanotubes (MWCNT) are well documented. However, systemic effects are less understood. Prospective epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particle...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-61366 | biostudies-arrayexpress
UnknownInstillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier.
Not available
S-EPMC6008127 | biostudies-literature
GenomicsmiRNA reponse to bleomycin instillation
Comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation: miRNA expression profiles were established from lungs derived from the two strains, following a 7- or 14-days PBS or bleomycin administration.
ORGANISM(S): Homo sapiens Mus musculus 
2013-02-01 | GSE34812 | GEO
GenomicsGene expression modification in lungs of rats exposed to DQ-12 by endotracheal instillation
Gene expression modification in lungs of rats exposed to DQ-12 by endotracheal instillation
PRJNA666925 | ENA
TranscriptomicsTranscriptomic analysis of mouse lung tissue exposed to two multiwalled carbon nanotubes (NRCWE-26 and NM-401)
Multi-walled carbon nanotubes (MWCNTs) are extensively produced and used in composite materials and electronic applications, thus increasing risk of worker and consumer exposure. MWCNTs are an inhomogeneous group of nanomaterials that exist in various lengths, shapes and with different metal composi...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55286 | biostudies-arrayexpress
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