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TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of breast cancer cells with Insulin like growth factor binding protein 2 (IGFBP2) knockdown
The study was carried out to identify the genes regulated upon IGFBP2 modulation in breast cancer. This will help to understand the molecular targets and biological pathways targeted by IGFBP2 in breast cancer. C5 (Cy5) Vs. Vector(Cy3), C5 (Cy5) Vs. Vector(Cy3), C12 (Cy5) Vs. Vector(Cy3), C12 (Cy5) ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-40682 | biostudies-arrayexpress
TranscriptomicsInsulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-M-NM-:B Pathway in Pancreatic Ductal Adenocarcinoma
IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role of IGFBP2 and its related pathways in PDAC. Gene expression profiling were used to reveal the key signaling pathways. Microarray experiments in IGFBP2-overexpressing ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-64611 | biostudies-arrayexpress
TranscriptomicsHuman liver biopsy of different phases from control to NASH
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (N=45) with all stages of NAFLD and controls (N=18) were analysed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific e...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-48452 | biostudies-arrayexpress
TranscriptomicsIGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB
Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing the IGFBP2 network, combining transcriptional profiling of human glioma with vali...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35467 | biostudies-arrayexpress
TranscriptomicsExpression data from E18.5 Igf1 -/- (homozygous mutant) and Igf1+/+ (normal wild type control) mouse lungs
Insight into the role of Insulin-like Growth Factor (IGF) in development of lungs has come from the study of genetically modified mice. IGF1 is a key factor during lung development. IGF1 deficiency in the neonatal mouse causes respiratory failure collapsed alveoli and altered alveolar septa. To furt...
ORGANISM(S): Mus musculus 
2014-03-31 | E-GEOD-17157 | biostudies-arrayexpress
UnknownQuantification of putative ovarian cancer serum protein biomarkers using a multiplexed targeted mass spectrometry assay.
Not available
S-EPMC10762856 | biostudies-literature
TranscriptomicsPRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells
Cord blood hematopoietic stem cells (CB-HSCs) are an outstanding source for transplantation approaches. However, the amount of cells per donor is limited and culture expansion of CB-HSCs is accompanied by a loss of engraftment potential. In order to analyze the molecular mechanisms leading to this i...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-58461 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the effect of elevated TRIB3 expression on the transcriptional response to glucose deprivation
Gene expression profiling of HEK293-derived cell lines that are stably transfected with either a tetracycline-inducible TRIB3 expression construct (TRIB3-293 cells), tetracycline-inducible ATF4 expression construct (ATF4-293 cells) or the corresponding empty vector (Vector-293 cells). Samples from t...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-MTAB-3318 | biostudies-arrayexpress
ProteomicsPlasma Proteomics in Patients with Age-related Sarcopenia
Data-independent acquisition-based proteomics was performed on plasma samples from 60 hospitalized participants, 30 with age-related sarcopenia and 30 without. In the data, label "A" represents "sarcopenia", and "B" represents "non-sarcopenia". This study was approved by the ethics committee of hosp...
ORGANISM(S): Homo Sapiens 
2024-07-07 | PXD053735 |
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