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TranscriptomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [RNA-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60585 | biostudies-arrayexpress
ProteomicsMutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly
IPs of integrator complex proteins from human and fly
ORGANISM(S): Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2023-03-10 | PXD020593 | Pride
Fly Lcms Human 
GenomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [ChIP-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60584 | biostudies-arrayexpress
ProteomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated with neurodevelopmental and neurodegenerative disorders characterized by heterogeneous phenotypes with varying levels of clinical severity. However, the underlying molecular mechanisms of disease pathology remain poo...
ORGANISM(S): Homo sapiens (Human) 
2022-08-30 | PXD028591 | Pride
Small nuclear rna Brat1 Integrator complex Neurodegeneration 
GenomicsThe Integrator complex cleaves many nascent mRNAs to attenuate transcription
The Integrator complex cleaves many nascent mRNAs to attenuate transcription
PRJNA561382 | ENA
GenomicsThe Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading
PRJNA738965 | ENA
TranscriptomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodeg...
ORGANISM(S): Homo sapiens 
2023-01-02 | E-MTAB-10750 | biostudies-arrayexpress
TranscriptomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60586 | biostudies-arrayexpress
ProteomicsA combinatorial approach to uncover a novel Integrator subunit
RNA polymerase II (RNAPII) controls the expression of all protein coding genes and most noncoding loci in higher eukaryotes. The ultimate rate of transcription is regulated at the level of multiple checkpoints during the transcription cycle (initiation, pausing, termination). Calibrating the activit...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039956 | Pride
Transcription Proteomics Integrator complex Functional genomics Alphafold2 
GenomicsINTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly
INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly
PRJNA645398 | ENA
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