Sort   by:  
 Page size 
TranscriptomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodeg...
ORGANISM(S): Homo sapiens 
2023-01-02 | E-MTAB-10750 | biostudies-arrayexpress
ProteomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated with neurodevelopmental and neurodegenerative disorders characterized by heterogeneous phenotypes with varying levels of clinical severity. However, the underlying molecular mechanisms of disease pathology remain poo...
ORGANISM(S): Homo sapiens (Human) 
2022-08-30 | PXD028591 | Pride
Small nuclear rna Brat1 Integrator complex Neurodegeneration 
ProteomicsNeuronal differentiation requires BRAT1 complex to remove REST from chromatin
Repressor element-1 silencing transcription factor (REST) is required for mature neurons formation. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST-mediated silencing of key neurogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050622 | Pride
Integrator Neuronal differentiation Brat1 
GenomicsNeuronal differentiation requires BRAT1 complex to remove REST from chromatin
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin
PRJNA994879 | ENA
TranscriptomicsNeuronal differentiation requires BRAT1 complex to remove REST from chromatin
Repressor element-1 silencing transcription factor (REST) is required for the formation of mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST-mediated silencing of key neurog...
ORGANISM(S): Homo sapiens 
2025-06-20 | GSE237396 | GEO
UnknownBRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction.
Not available
S-EPMC4129107 | biostudies-literature
UnknownBRAT1 - a new therapeutic target for glioblastoma.
Not available
S-EPMC11747058 | biostudies-literature
UnknownBRAT1 links Integrator and defective RNA processing with neurodegeneration.
Not available
S-EPMC9418311 | biostudies-literature
UnknownNeuronal differentiation requires BRAT1 complex to remove REST from chromatin.
Not available
S-EPMC11161795 | biostudies-literature
UnknownBRAT1 Mutation Retrospective Diagnosis: A Case Report.
Not available
S-EPMC10065748 | biostudies-literature
Sort   by:  
 Page size