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TranscriptomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [RNA-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60585 | biostudies-arrayexpress
ProteomicsMutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly
IPs of integrator complex proteins from human and fly
ORGANISM(S): Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2023-03-10 | PXD020593 | Pride
Fly Lcms Human 
GenomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [ChIP-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60584 | biostudies-arrayexpress
ProteomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated with neurodevelopmental and neurodegenerative disorders characterized by heterogeneous phenotypes with varying levels of clinical severity. However, the underlying molecular mechanisms of disease pathology remain poo...
ORGANISM(S): Homo sapiens (Human) 
2022-08-30 | PXD028591 | Pride
Small nuclear rna Brat1 Integrator complex Neurodegeneration 
TranscriptomicsBRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodeg...
ORGANISM(S): Homo sapiens 
2023-01-02 | E-MTAB-10750 | biostudies-arrayexpress
ProteomicsA combinatorial approach to uncover a novel Integrator subunit
RNA polymerase II (RNAPII) controls the expression of all protein coding genes and most noncoding loci in higher eukaryotes. The ultimate rate of transcription is regulated at the level of multiple checkpoints during the transcription cycle (initiation, pausing, termination). Calibrating the activit...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039956 | Pride
Transcription Proteomics Integrator complex Functional genomics Alphafold2 
ProteomicsIntegrator restraints paraspeckles assembly by promoting the 3’-end processing of the polyadenylated lncRNA NEAT1_1
Alternative 3’-end RNA processing provides an important source of transcriptome diversification, which impacts various biological processes and the etiology of diseases, including cancer. Here, we focused on a transcript isoform switch that leads to the readthrough expression of the long noncoding R...
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD015158 | Pride
Cancer Neat1  alternative 3’-end rna processing Integrator Paraspeckles 
ProteomicsCharacterization of Integrator module INTS10-INTS13-INTS14 and its connection to the cleavage module Part I
Chemical cross-linking coupled to mass spectrometry was used to study the complex between the Integrator complex subunits INTS13 (Asunder) and INTS14. Cross-linking was performed using disuccinimidyl suberate (DSS).
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD015682 | Pride
Chemical cross-linking  dss  structural proteomics  integrator complex 
ProteomicsCharacterization of Integrator module INTS10-INTS13-INTS14 and its connection to the cleavage module Part II
Chemical cross-linking coupled to mass spectrometry was used to study the complex between the Integrator complex subunits INTS4, 9, 11, and a partial segment of INTS13 containing the C-terminal region (termed CMBM). Cross-linking was performed using disuccinimidyl suberate (DSS).
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD017996 | Pride
Chemical cross-linking  dss  structural proteomics  integrator complex 
GenomicsA ZBTB26–Integrator axis mediates targeted transcriptional activation
A ZBTB26–Integrator axis mediates targeted transcriptional activation
PRJNA1449466 | ENA
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