Sort   by:  
 Page size 
TranscriptomicsTimecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)
The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the p...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42504 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of naïve and in vitro effector CD8+ T cells from wild-type and BATF-/- mice
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54215 | biostudies-arrayexpress
TranscriptomicsInterferon-Gamma- and Murine-CMV-Activated Primary Macrophages
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42505 | biostudies-arrayexpress
TranscriptomicsInterferon alfa regulated gene expression in patients initiating interferon treatment for chronic hepatitis C
Interferon alfa (IFN-alpha) is an approved therapeutic agent for chronic hepatitis C. To directly characterize the effects of IFN-alpha in humans, we used microarrays to profile gene expression in peripheral blood mononuclear cells (PBMCs) from hepatitis C patients treated with IFN-alpha. Seven pati...
ORGANISM(S): Homo sapiens 
2006-01-31 | E-GEOD-4134 | biostudies-arrayexpress
TranscriptomicsGene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells
Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LC...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17211 | biostudies-arrayexpress
TranscriptomicsInfluence of Interferon-beta on expression profile of memory T-cells
Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1beta. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in autoimmune diseases, but the mechanisms controlling the activation of human infl...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-35601 | biostudies-arrayexpress
GenomicsB cell derived type I interferon promotes T cell effector function during chronic infection
B cell derived type I interferon promotes T cell effector function during chronic infection
PRJNA1227605 | ENA
TranscriptomicsExpression data from RAW264.7 murine macrophages infected with Toxoplasma gondii and subsequently stimulated with interferon-gamma
Toxoplasma strains are known to inhibit the expression of several interferon-gamma induced genes, and a type II strain was shown to dysregulate genome-wide responses to interferon-gamma in human fibroblasts (Kim et al., 2007, J Immunol.). In this study we aimed to determine the effect of infection ...
ORGANISM(S): Mus musculus 
2013-02-19 | E-GEOD-34913 | biostudies-arrayexpress
Sort   by:  
 Page size