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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
ProteomicsInterferon Regulatory Factors: IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection.
Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with IFNα signalling. Here we show IRF1,3 and 7 levels are elevated in most bat tissues and that basally, IRFs contribute to the expression of type I IFN ligands and high expression of Interferon Regula...
ORGANISM(S): Cellular Organisms 
2020-10-23 | PXD021982 | JPOST Repository
TranscriptomicsTranscription profiling time series of the response of human microglial cells to interferon gamma
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1432 | biostudies-arrayexpress
ProteomicsHomeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Host defense by the innate immune system requires the establishment of antimicrobial states allowing cells to cope with microorganisms before the onset of the adaptive immune response. Interferons (IFN) are of vital importance in the establishment of cell-autonomous antimicrobial immunity. Speed is...
ORGANISM(S): Mus Musculus 
PXD013251 | panorama
TranscriptomicsTimecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)
The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the p...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42504 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the response to interferon beta in EBV-transformed and primary B cells of patients with multiple sclerosis
To identify gene expression changes and pathways induced by interferon-? (IFN-?) in B cells, we studied the in vitro response of EBV-transformed B cells (lymphoblast cell lines-LCLs). LCLs were derived from an MS patient repository. Whole genome expression analysis identified 115 genes that were mor...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-58240 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human dermal fibroblasts with STAT2 deficiency and control fibroblasts treated with interferon
Primary human dermal fibroblasts were isolated from an individual showing a genetic defect in innate antiviral immunity associated with profound failure of type 1 interferon signaling and absence of the STAT2 protein. The transcriptional response of these cells to a 10h treatment with interferon-alp...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-41960 | biostudies-arrayexpress
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
GenomicsHistone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (sequencing)
Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of ...
ORGANISM(S): Mus musculus 
2012-03-02 | E-GEOD-22102 | biostudies-arrayexpress
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