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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
TranscriptomicsDynamic expression profiling of type I and type III interferon-stimulated hepatocytes.
This dataset details the time-dependent response of human Huh7 hepatoma cells to type I and type III IFN. Despite activating similar signaling cascades, the type I and type III interferons (IFNs) differ in their ability to antagonize viral replication. However, it is not clear whether these cytokine...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-48400 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
TranscriptomicsType I interferon signaling is required for activation of the inflammasome during Francisella infection
Francisella are pathogenic bacteria whose virulence is linked to their ability to replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host protective multimolecular complex called the inflammasome to release the proinflammatory cytokines IL-1 and IL-18 and trigger c...
ORGANISM(S): Mus musculus 
2007-05-23 | E-GEOD-7684 | biostudies-arrayexpress
TranscriptomicsType I and II Interferon-Stimulated Genes in Murine Primary Bone Marrow Macrophages
We used microarrays to compare interferon-alpha (IFNa)- and interferon-gamma (IFNg)-stimulated genes under an equivalent biological input. The goal was to compare IFNa- and IFNg-stimulated genes, as well as to identify common and distinct sets of type I and II ISGs. Bone marrow macrophages derived f...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-35825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Atlantic salmon cell line SHK-1 exposed to interferon type 1 and interferon gamma for 6 or 24 hours
We have stimulated an Atlantic salmon cell line, SHK-1, with both type I and type II recombinant salmonid IFNs and analysed the transcriptional response by microarray analysis. Cells were exposed to recombinant IFNs for 6 or 24 h or were left unexposed as controls. RNA was hybridised to a 17k feat...
ORGANISM(S): Salmo salar 
2007-10-08 | E-MEXP-1023 | biostudies-arrayexpress
TranscriptomicsTLR-mediated type I IFN induction in pDCs requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
Robust type I interferon (IFN-alpha/beta) production in plasmacytoid dendritic cells (pDCs) is critical for anti-viral immunity. Here we demonstrated a role for the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or the ‘downstream’ mediat...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human psoriasis patient matched lesion and normal tissue vs. normal controls - type i interferon: potential therapeutic target for psoriasis?
We observed robust overexpression of type I interferon (IFN)-inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dend...
ORGANISM(S): Homo sapiens 
2009-03-01 | E-GEOD-14905 | biostudies-arrayexpress
GenomicsIKK-epsilon regulates the balance between the type I and type II interferon responses
Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, S...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress
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