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TranscriptomicsAlternatively Spliced Variants of Interleukin-4 Promote Inflammation Differentially
IL-4d2 is a natural splice variant of IL-4 which lacks the region encoded by the second exon. Numerous recent reports suggested that the expression levels of IL-4d2 change in various diseases, especially those with pulmonary involvement, but the effects of IL-4d2 on the lungs in vivo have never been...
ORGANISM(S): Mus musculus 
2011-03-07 | E-GEOD-23016 | biostudies-arrayexpress
TranscriptomicsInterleukin-4 and interleukin-13 cytokines effect on epidermal keratinocytes
Analysis of cultured epidermal keratinocytes treated with interleukin-4 (IL-4) and interleukin-13 (IL-13). IL-4 and IL-13 are up-regulated in atopic dermatitis. Results provide insight into the role of IL-4 and IL-13 cytokines in the pathogenesis of atopic dermatitis. Analysis of epidermal keratino...
ORGANISM(S): Homo sapiens 
2010-10-31 | E-GEOD-20706 | biostudies-arrayexpress
GenomicsInterleukin-4 receptor signaling modulates neuronal network activity
Interleukin-4 receptor signaling modulates neuronal network activity
PRJNA825260 | ENA
TranscriptomicsRole of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [B]
T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-39858 | biostudies-arrayexpress
GenomicsInterleukin-4 receptor signaling modulates neuronal network activity [mouse]
Interleukin-4 receptor signaling modulates neuronal network activity [mouse]
PRJNA825385 | ENA
TranscriptomicsIL-4 mediated gene expression profiles in vascular endothelial cells
Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin (IL)-4 markedly induced vascular cell adhesion molecule (VCAM)-1, both in cultured endothelial cells and in the intact endothelium in mice. Combine...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-28117 | biostudies-arrayexpress
MetabolomicsClostridium butyricum MIYAIRI 588-induced protectin D1 has an anti-inflammatory effect on antibiotic-induced intestinal disorder
Metabolites are thought as the end products in cellular regulatory processes and their levels show the strongest relationships with the phenotype. Previously, we showed that the administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated protectin D1, an anti-inflammatory lipid metabol...
2020-10-14 | MTBLS2087 | MetaboLights
TranscriptomicsmiRNA regulation by interleukin-4 (IL-4) in chronic lymphocytic leukemia (CLL)
miRNA expression profiles of CLL cells and normal B cells (NBC) treated for 18 hr with 10 ng/ml IL-4, compared with culture with nothing (Ctrl) and the basal (Pre) samples. 16 CLL patients (8 Pre samples, 15 Ctrl samples, 15 IL-4 samples), 3 NBC (3 Ctrl samples, 3 IL-4 samples)
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-62137 | biostudies-arrayexpress
TranscriptomicsRole of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [A]
T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-39862 | biostudies-arrayexpress
TranscriptomicsIdentification of interleukin-4 (IL-4) targets in chronic lymphocytic leukemia (CLL)
Gene expression profiles of CLL cells and normal B cells (NBC) treated for 18 hr with 10 ng/ml IL-4, compared with culture with nothing (Ctrl) and the basal (Pre) samples. Patient CLL01 was also treated with IL-4 plus 5 mg/ml ERK activation inhibitor peptide I, or IL-4 plus 10 µM NFkB activation in...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-55288 | biostudies-arrayexpress
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