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MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
ProteomicsInternalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Internalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity" by Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-26 | MSV000095695 | MassIVE
ProteomicsDevelopment and qualification of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Development and characterization of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics" by Michel Siegel, Aman Padamse...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095578 | MassIVE
ProteomicsCellular internalization pathways of environmentally exposed microplastic particles
Microplastic particles that occur in the environment are coated with different biomolecules forming an eco-corona on the particles' surface, which could consequently lead to a specific interaction of the constituents of the eco-corona with membrane receptors. To date, it is not fully understood how ...
ORGANISM(S): biofilm metagenome 
2025-03-07 | PXD050078 | Pride
Eco-corona Microplastic 
TranscriptomicsTranscription profiling of intramacrophage Burkholderia cenocepacia K56-2
Effect of internalization by macrophages on bacterial gene transcription in Burkholderia cenocepacia
ORGANISM(S): Burkholderia cenocepacia 
2011-12-07 | E-MEXP-3408 | biostudies-arrayexpress
ProteomicsIsoform-dependent lysosomal degradation and internalization of Apolipoprotein E requires autophagy proteins
Alzheimer’s disease (AD), and lysosomal dysfunction has been implicated in AD pathogenesis. We found, by examining cells stably expressing each APOE isoform, that APOE4 increases lysosomal trafficking, accumulates in enlarged lysosomes and late endosomes, alters autophagic flux and the abundance of ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-18 | PXD031016 | Pride
Alzheimers apoe apoe4 chaperone-mediated autophagy lc3 
GenomicsTracking of Individual Cell Populations by 19F MRI using a "Cargo Internalization Receptor (CIR)" System
Tracking of Individual Cell Populations by 19F MRI using a "Cargo Internalization Receptor (CIR)" System
PRJNA415943 | ENA
ProteomicsInhibition of ß1 integrin induces its association with MT1-MMP and decreases MT1- MMP internalization and cellular invasiveness
Integrin signaling plays a fundamental role in the establishment of focal adhesions and the subsequent formation of invadopodia in malignant cancer cells. Invadopodia facilitate localized adhesion and degradation of the extracellular matrix (ECM), which promote tumour cell invasion and metastasis. D...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD024000 | Pride
Extracellular matrix  integrin  mt1-mmp  invadopodia 
GenomicsEffects of HMGA1 internalization in melanoma cells [ATACseq_reHMGA1]
Effects of HMGA1 internalization in melanoma cells [ATACseq_reHMGA1]
PRJNA1142520 | ENA
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